PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFEC

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是观察葡萄糖代谢(身体如何分解血糖)，血液中脂肪(脂肪)、蛋白质和其他物质的数量，体脂和脂肪的数量分布，以及骨骼的致密程度：a)感染艾滋病毒的儿童与未感染艾滋病毒的儿童比较；b)感染艾滋病毒的儿童和处于性发育不同阶段的未感染儿童；c)感染艾滋病毒的儿童服用一种名为蛋白酶抑制剂(PI)的抗艾滋病毒药物，与未服用PIs的艾滋病毒感染儿童进行比较。大约450名儿童将参加这项研究，他们来自港湾-加州大学洛杉矶分校的7-14岁。这孩子要做两次特殊的X光检查。这些X射线被称为双能X射线吸收法(DEXA)扫描。其中一种X光将扫描全身，另一种将只扫描脊柱和臀部。孩子的身高和体重将被测量。孩子腰部、臀部、手臂和大腿周围的距离将用卷尺测量。孩子的手臂、肩膀、腹部、臀部和大腿的皮肤折叠度将使用卡尺测量，卡尺是一种看起来像钳子的无害设备。孩子们将被要求回答一些关于他/她的身体形象和外表变化的问题。孩子们会被问到一些问题，比如孩子通常吃什么食物，以及孩子多长时间吃一次。儿童还将被问到关于来诊所的前一天吃的食物的具体问题。将进行常规和特殊的血液测试。研究将在30天内进行1次访问(3小时)至3次访问(每次1-2小时)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to look at glucose metabolism (how the body breaks down blood sugar), the amounts of lipids (fats), proteins, and other substances in the blood, the amount of body fat and fat distribution, and how dense (solid) bones are in: a) HIV-infected children compared to HIV-uninfected children; b) HIV-infected children and uninfected children at different stages of sexual development; c) HIV infected children taking a class of anti-HIV drugs called protease inhibitors (PIs) compared to HIV-infected children not taking PIs. About 450 children will take part in this study, 7-14 from the Harbor-UCLA site. The child will have two special x-rays done. These x-rays are called dual energy x-ray absorptiometry (DEXA) scans. One of the x-rays will scan the whole body and the other x-ray will scan just the spine and hip. The child's height and weight will be measured. The distance around the child's waist, hips, arm and thigh will be measured using a measuring tape. Folds of skin will be measured at the child's arm, shoulder, stomach, hip and thigh using calipers, a harmless device that looks like pliers. The child will be asked to answer some questions about changs in his/her body image and appearance. The child will be asked some questions about the kinds of food the child eats normally and how often the child eats. The child will also be asked specific questions about the food the child ate the day before he/she came to the clinic. Routine and special blood tests will be drawn. The study will be from 1 visit (3 hrs) to 3 visits (each 1-2 hrs) within 30 days.