PREVALENCE OF VITAMIN D DEFICIENCY IN PATIENTS ADMITTED TO REHABILITATION UNIT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。维生素D缺乏被认为是一个过去的问题，因此不是医学界治疗的重点。事实是，维生素D缺乏是一个在所有年龄段和各种种族中都能看到的慢性问题。最近，人们认识到维生素D缺乏是住院和疗养院患者中特别常见的问题。高龄、维生素D摄入量不足和居家生活使患者维生素D缺乏的风险增加，但单凭这些因素不足以预测维生素D缺乏症。维生素D的状态对急性病或手术后最近住院的患者的健康和福祉很重要。鉴于在过渡期护理病房接受康复治疗的患者群体的性质，我们认为确定这一亚组中维生素D缺乏症的流行情况是重要的。因此，我们有兴趣测定25-羟基维生素D[25(OH)D]、甲状旁腺激素、钙、白蛋白和碱性磷酸酶。我们将通过测量骨密度和血清CTX-骨吸收活性的测定来表征骨质疏松的程度。所有参与者都将填写一份调查问卷，其中包括人口统计信息、阳光暴露史、相关的医疗和用药史。我们计划检测25(OH)D、甲状旁腺激素、钙、白蛋白、碱性磷酸酶和血清CTX。入院时常规采血，采血20毫升。患者还将接受骨密度测量。不需要其他研究程序，也不需要其他研究访问。患者将不会因参与而获得补偿。这是一项观察性研究，旨在确定入住康复机构的患者中维生素D的缺乏情况，并确定该人群中骨质疏松的程度。有趣的结果是25(OH)D、钙、碱性磷酸酶、白蛋白、甲状旁腺激素、血清环磷酰胺和骨密度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vitamin D deficiency is assumed to be a problem of the past and therefore not in the forefront of treatment by the medical community. The truth is vitamin D deficiency is a chronic problem seen in all age groups and a variety of ethnic groups. Recently, it is recognized that vitamin D deficiency is an especially common problem in hospitalized and nursing home patients. Advanced age, inadequate vitamin D intake, and housebound living put patients at increased risk for Vitamin D deficiency, but on its own are insufficient to predict hypovitaminosis. The vitamin D status is important for the health and well being of patients after recent hospitalization after an acute illness or surgery. Given the nature of patient population admitted for rehabilitation at the Transitional Care Unit, we believe that it is important to characterize the prevalence of vitamin D deficiency in this subgroup. Thus, we are interested in measuring 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium, albumin and alkaline phosphatase. We will characterize the extent of osteoporosis by measuring bone density and serum CTX - the assay for measurement of bone resorption activity. All participants will fill out a questionnaire with demographic information, history of sun exposure, pertinent medical and medication history. We plan on measuring 25(OH)D, parathyroid hormone, calcium, albumin, alkaline phosphatase, and serum CTX. 20 mL of blood will be collected from the patients during routine blood draw at the time of admission. Patients will also undergo bone densitometry. There are no other study procedures required and there are no other study visits required. Patients will not be compensated for participation. This is an observational study to determine deficiency of vitamin D in patients admitted to the rehabilitation facility as well as to characterize extent of osteoporosis in this population. The outcomes of interest are the levels of the 25 (OH)D, calcium, alkaline phosphatase, albumin, parathyroid hormone, serum CTX and bone density.