CALCIUM METABOLISM IN ASIAN ADOLESCENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。先前的研究（GCRC协议0451）在青少年白人和黑人女孩和男孩中建立了膳食钙摄入量，优化了这些群体的骨骼钙潴留。该方案包括在普渡大学进行为期2周的钙平衡，在平衡的第一天在GCRC上进行钙动力学。在高钙摄入和低钙摄入的情况下，每个受试者间隔一个月进行两次平衡，钙摄入量范围在600-2300毫克/天之间。我们现在建议在美籍华人青少年中研究同样的关系。主要目的是确定钙的需求，以优化亚洲女孩和男孩的骨骼钙潴留。第二个目的是将亚洲人的数据与我们已经收集到的美国白人和黑人的数据进行比较，长期目标是在快速生长时期确定最佳的钙摄入量，以建立峰值骨量，降低患骨质疏松症的终身风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous work ( GCRC protocol 0451) in adolescent white and black girls and boys has established the dietary calcium intake that optimizes skeletal calcium retention in these groups. The protocol involves a 2 week calcium balance at Purdue with calcium kinetics performed on the GCRC on day one of the balance. Two balances are performed one month apart on each subject on a high and low calcium intake with the range of calcium intakes lying between 600-2300 mg/d. We now propose to study these same relationships in Chinese American adolescent girls and boys. The primary aim is to establish the calcium requirement that optimizes skeletal calcium retention in Asian girls and boys. A secondary aim is to compare the data in Asians with those we have already collected in American whites and Blacks The long term goal is to establish the optimal calcium intake during periods of rapid growth in order to build peak bone mass and reduce lifelong risk of osteoporosis.