MCT OIL FOR WEIGHT LOSS/GLYCEMIC CONTROL IN OBESE DIABETIC PT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。2型糖尿病是与肥胖，特别是中腹部肥胖相关的几种合并症之一。研究表明，适度减肥（体重的5-10%）可以改善2型糖尿病患者的血糖控制；然而，肥胖患者通常很难通过改变行为、控制饮食和锻炼来减肥和维持体重。对于体重指数为bb0 ~ 27kg /m2且减肥失败的糖尿病患者，可以考虑特殊配方饮食和/或药物治疗。中链甘油三酯（MCT）含有6-12碳链长度的脂肪酸，是牛奶、椰子油和棕榈仁油的天然成分。先前的研究表明，MCT衍生的中链脂肪酸（MCFA）在体内和体外都比作为脂肪储存更容易被氧化（1,2）。给动物喂食MCT导致脂肪细胞数量减少，脂肪细胞尺寸变小(3)。此外，我们最近的研究结果表明，MCFAs抑制前脂肪细胞向脂肪细胞的分化，并下调成熟脂肪细胞的成脂基因。总之，这些结果表明，包括MCT在内的饮食可能对控制体重有用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes mellitus is one of several co-morbid conditions associated with obesity, particularly central abdominal obesity. It has been demonstrated that modest weight loss (5-10% of total body weight) improves glycemic control in type 2 diabetic patients; however, obese patients usually have extreme difficulty in losing weight and maintaining that weight loss with behavioral modification, diet control, and exercise. Special formula diets and/or pharmacotherapy are considered in diabetic patients with a BMI>27 kg/m2 who have previously failed in weight reduction attempts. Medium chain triglycerides (MCT) that contain fatty acids with 6-12 carbon chain lengths are natural components of milk, coconut oil and palm kernel oils. Previous studies showed that MCT derived medium chain fatty acids (MCFA) are more oxidized than stored as fat both in vivo and in vitro (1,2). Feeding MCT to animals resulted in reduced fat cell numbers and smaller fat cell sizes (3). Moreover, our recent findings showed that MCFAs inhibit preadipocyte differentiation into fat cells and also down-regulate adipogenic genes in mature adiocytes. Together, these results suggest that a diet including MCT could potentially be useful for weight control.