H/H-ASTHMA HGC

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。哮喘是一种复杂的、多因素的疾病，是多种基因产物和环境因素之间的生物学相互作用的结果。目前认为遗传学在哮喘的病理生理学中起着重要的作用，并发表了非裔美国人哮喘发病率较高以及相关的发病率和生育率的报告，因此需要进行更多的研究来确定可归因于哮喘发展的遗传因素。本研究的目的是确定导致哮喘发生的遗传危险因素。我们计划在华盛顿招募100名哮喘患者。C.对于这项研究的领域。与约翰霍普金斯大学的合作者一起，我们的目标是鉴定赋予人类对蟑螂过敏原的特异性IgE免疫反应易感性的等位基因变体。哮喘易感等位基因的鉴定将有助于更好地了解其发病机制，最终目标是改善这种疾病的预防策略，诊断工具和治疗方法，这种疾病现在是人们特别是非洲裔美国人的主要健康和经济负担。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a complex, multifactorial disease resulting from biologic interaction between multiple gene products and environmental factors. The current thoughts that genetics play a major role in asthma pathophysiology and published reports of higher incidence of asthma and assoicated morbidity and mortlity in African American, it sems imperative that more studies are needed to identify genetic factors attributable to asthma development. The purpose of this study is to identify genetic risk factors contributing towards development of asthma. We plan to recruit 100 asthma patients in the Washington, D. C. area for this study. With our collaborators at Johns Hopkins University, we aim to identify allelic variants that confer susceptibility towards a specific IgE immune response to cockroach allergen in humans. Identification of asthma susceptible alleles will help in better understanding of its pathogenesis, with the ultimate goal of improving preventive strategies, diagnostic tools, and therapies for this disease which is now a major health and economic burden for peoples especially in African Americans.