EFFICACY OF SPINAL KETOROLAC TO REDUCE EXPERIMENTAL PAIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。之所以进行这项研究，是因为疼痛对于有各种医疗问题的患者以及手术或创伤后的患者来说是一个重要的问题。目前可用的止痛药可能不能缓解所有类型的疼痛，或者只能在产生副作用和潜在并发症的剂量下缓解疼痛。这项研究中的药物可能在更好地治疗疼痛方面发挥作用。这项研究的目的是观察脊椎注射剂量的酮咯酸(非麻醉性止痛药)(注入背部靠近脊柱的液体中)是否对我们将暴露在少量UV-B辐射(轻度晒伤)下的一小部分皮肤的疼痛或不适有任何影响。正在研究的药物是FDA批准的药物；然而，我们根据IND 62,179进行这项研究，因为我们通过与指示的不同的途径给药。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury. Currently available pain medications may not relieve all types of pain or may relieve pain only at doses that produce side effects and potential complications. The medication in this study may have a role in better treatment of pain. The goals of this study are to see if a dose of ketorolac (non-narcotic pain reliever), given spinally (given into the fluid in the back near the spine) has any effect on pain or discomfort from a small area of skin that we will expose to a small amount of UV-B radiation (a mild sunburn). The medication being studied is an FDA approved medication; however, we are conducting this study under IND 62,179 because we are administering the medication by a different route than it is indicated for.