PACTG 1025

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。PACTG P1025是一项前瞻性队列研究，为收集和评估艾滋病毒感染孕妇和产后妇女及其婴儿的数据和收集存储库标本提供了框架。这项研究的主要目标是：评估预防艾滋病毒垂直传播和/或妇女健康规定的干预措施（例如抗逆转录病毒治疗和分娩方式）的有效性；评估为妇女健康和/或预防艾滋病毒垂直传播而规定的干预措施（例如抗逆转录病毒疗法和分娩方式）的物质和婴儿安全性；为深入的子研究（如PACTG P1026s，妊娠期药代动力学）、新工作概念表（NWCS）和数据分析概念表（DACS）提供框架和标本库，旨在进一步阐明艾滋病毒垂直传播的危险因素和机制，以及影响母婴结局的因素；评估感染艾滋病毒的孕妇在怀孕期间和产后坚持抗逆转录病毒治疗的情况及其对妇女健康和垂直传播的影响，并评估婴儿坚持化疗预防的情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PACTG P1025 is a prospective cohort study that provides a framework for collection and evlauation of data and collection of repository specimens from HIV-infected pregnant and postpartum women and their infants. The primary objectives of this study are: to assess the effectiveness of interventions (e.g. antiretroviral therapy and mode of delivery) prescribed for prevention of vertical transmission of HIV and/or for women's health; to assess material and infant safety of interventions (e.g. ART and mode of delivery) prescribed for women's health and/or for prevention of vertical transmission of HIV; to provide a framework and specimen repository for intensive substudies (such as PACTG P1026s, pharmacokinetics in pregnancy), New Works Concept Sheets (NWCS) and Data Analysis Concept Sheets (DACS) that aim to further elucidate risk factors for and mechanisms of vertical transmission of HIV, as well as factors that affect maternal and infant outcomes; to assess adherence to ART among HIV-infected pregnant women during pregnancy and postpartum and its impact on women's health and vertical transmission, and to assess adherence to chemoprophylaxsis in infants.