PET STUDIES OF COCAINE ABUSE: EFFECTS OF EXPECTATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的目的是观察当受试者期望接受一种物质时大脑的反应，这种物质会引起类似可卡因（哌甲酯）的大脑反应，而不是当他们实际接受哌甲酯时的大脑反应。这将在注射哌甲酯或安慰剂后使用磁共振成像（MRI）跟踪放射性示踪剂（注射到血流中的放射性化学物质）来完成。还将通过要求可卡因滥用者在整个研究期间报告当前的感觉和情绪来测量主观测量，并将这些主观报告与PET扫描进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the study is to look at reactions in the brain when a subject is expecting to receive a substance that causes a reaction in the brain similar to cocaine (methylphenidate) as opposed to the brain reaction when they actually receive methylphenidate. This will be done using Magnetic Resonance Imaging (MRI) to track a radiotracer (a radioactive chemical that is injected into the bloodstream) after the methylphenidate or a placebo is injected. Subjective measures will also be measured by asking cocaine abusers to report current feelings and mood throughout the study, and compare these subjective reports with the PET scans.