CANCER GENETICS REGISTRY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。癌症的遗传特性已被注意多年。5%到10%的癌症是由遗传性癌症综合症引起的。在确定与特定遗传性癌症综合征相关的遗传改变方面取得了进展。然而，对于许多癌症的最佳筛查和预防措施尚未确定，许多癌症的遗传成分仍未确定。这个研究项目是研究癌症的遗传基础。这项研究的目的是确定与癌症风险和发展相关的基因改变，并利用这些信息改进癌症风险个人和家庭的识别、筛查和管理。参与者将被要求提供个人和家族病史信息，并提供血液和肿瘤组织样本用于癌症遗传学研究。将定期与参与者联系，以更新他们的医疗和家族史信息，并要求他们与家庭成员分享有关登记的信息。本研究的个别结果不能报告，但可以通知参与者总体研究结果。本研究没有计划结束日期。研究人员计划尽可能长时间地继续识别和跟踪这些家庭。但是，参与者可以随时选择退出。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hereditary nature of cancer has been noted for many years. Between five to ten percent of cancers are due to hereditary cancer syndromes. Developments have been made in the identification of genetic alterations associated with specific hereditary cancer syndromes. However, for many cancers optimal screening and preventive measures have not yet been determined, and the hereditary components of many cancers remain unidentified. This research project is studying the genetic basis of cancer. The goals of this research are to identify genetic alterations associated with cancer risk and development, and to use this information to improve the identification, screening, and management of individuals and families at-risk for cancer. Participants will be asked to provide information about their personal and family medical history information and to give samples of blood and tumor tissue to be used for cancer genetics research. Participants will be contacted periodically to update their medical and family history information, and they will be asked to share information about the registry with family members. Individual results from this research cannot be reported, but participants can be notified of overall study findings. There is no planned end date for this study. The researchers plan to continue to identify and follow families for as long as possible. However, participants can chose to withdraw at any time.