EXERCISE AND FITNESS IN CHILDHOOD CANCER SURVIVORS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。符合纳入和排除标准的几种癌症类型的长期幸存者将被随机分配到干预条件（IC）或控制条件（CC）。干预条件结合了一个正式的运动训练计划，以个性化的形式提供标准的教育材料，在我们的ACCESS癌症幸存者计划中提供。控制条件包括提供教育材料，没有正式的锻炼计划。两组人还将继续幸存者通常可能参与的体育活动。每种情况将分配20名受试者。IC受试者将接受为期12周的有氧运动和体育活动计划，同时进行健康和健身教育。CC受试者将只接受健康和健身教育。主要结果测量，包括DEXA扫描，将在干预开始（第0周）和干预结束（第12周）时对IC和CC受试者进行，并在三个月随访（第24周）时再次进行。主要结果指标将评估身体功能和健康相关生活质量的具体方面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Long-term survivors of several cancer types who meet the inclusion and exclusion criteria will be randomized to either the Intervention Condition (IC), or to the Control Condition (CC). The Intervention Condition combines a formalized program of exercise training, provided in an individualized format with the standard educational material provided in our ACCESS cancer survivorship program. The Control Condition includes provision of educational material, without a formal exercise program. Both groups will also continue whatever physical activities the survivor might normally engage in. 20 subjects will be assigned to each condition. IC subjects will receive a 12 weeklong aerobic exercise and physical activity program, coupled with health and fitness education. CC subjects will receive only the health and fitness education. Primary outcome measures, including DEXA scans, will be administered to both the IC and CC subjects at the beginning (week 0) and the end of the intervention (week 12), and again at three-month follow-up (week 24). The primary outcome measures will evaluate specific aspects of physical functioning and health-related quality of life.