GENERAL CLINICAL RESEARCH CENTER

超出空间 但前提是。 这项赠款提案寻求继续支持埃默里综合临床研究中心(GCRC)的资金 亚特兰大大学医学院，包括埃默里大学医院的主要GCRC(自1960年以来资助)， 和格雷迪纪念医院的卫星GCRC(开放一年半)。埃默里GCRC计划的目标跨越 NCRR指南，提供：1)人体生理学和病理生理学研究的最佳环境；2)a 便于调查人类疾病的原因和自然病史以及疾病进展的定义， 预防、控制和治疗；3)将基础科学知识的进步迅速转化为 疾病识别和病人护理的范式转换方法；以及4)培训保健的机构资源 来自多个学科的临床研究专业人员。此应用程序总结了所进行的临床研究 自上一次提交以来，秘书处一直在执行这项工作，并提出了下一个周期的拟议活动。埃默里GCRC将 根据翻译研究在埃默里大学校园的位置优化翻译研究的机会，而格雷迪 卫星GCRC将利用其位于市中心一家医院的优势，专注于自然历史， 机制，以及对格雷迪服务的人群中更普遍的疾病的管理，如钝化 头部创伤、镰状细胞疾病、HI-V/ADS、低出生体重、酗酒、精神疾病和糖尿病； 少数民族在健康方面的差异部分是由于在医学研究研究中缺乏代表性。 针对这类人群中特别常见的情况，格雷迪卫星GCRC应有助于 解决这个问题。埃默里和格雷迪卫星的协议和主要调查人员的数量 GCRC稳步增长，反映了教职员工广泛的研究兴趣。本申请包含 87个不同的方案，埃默里医学院、公共卫生和护理学院的教职员工参与其中， 还有莫尔豪斯医学院。我们将GCRC计划的广泛使用归因于以下几个因素的结合 促进GCRC工作人员和教职员工的临床研究，提供GRADY卫星GCRC，招聘 学院临床研究人员，以及NIH对临床研究职业生涯支持的承诺，以个人为例 和机构的K系列奖项；Emory拥有K12和K30节目，以及许多K12和K23支持的节目 教职员工利用GCRC。埃默里的新研究战略计划非常强调翻译和整合 多学科研究，埃默里GCRC计划(在大学和城市医院环境中都有单位)是 预计将在这一努力中发挥重要作用-应用尖端、最先进的工具和方法来生产 促进人类健康所需的关键新知识。

EXCEED THE SPACE PROVIDED. This grant proposal seeks funding to continue support for the General Clinical Research Center (GCRC) at the Emory University School of Medicine in Atlanta, including the main GCRC at Emory University Hospital (funded since 1960), and a satellite GCRC at Grady Memorial Hospital (open for 1.5 years). The Emory GCRC Program goals span the NCRR guidelines by providing: 1) an optimal setting for the study of human physiology and pathophysiology; 2) a facility for the investigation of the cause and natural history of human illness and the definition of disease progression, prevention, control, and cure; 3) the means for the rapid translation of advances in basic scientific knowledge into paradigm-shifting methods for disease identification and patient care; and 4) institutional resources for training health professionals from multiple disciplines in clinical investigation. This application summarizes clinical research carried out since the previous submission, and presents the activities proposed for the next cycle. The Emory GCRC will optimize opportunities for translational research based on its location on the Emory University campus, while the Grady satellite GCRC will take advantage of its location at an inner-city hospital, and focus on the natural history, mechanisms, and management of disorders that are more prevalent in the population that Grady serves, such as blunt head trauma, sickle cell disease, HI-V/ADS, low birth weight, alcoholism, psychiatric conditions, and diabetes; the disparities in health suffered by ethnic minorities are due in part to lack of representation in medical research studies aimed at conditions which are particularly common in such populations, and the Grady satellite GCRC should help to solve this problem. The number of protocols and principal investigators at both the Emory and the Grady satellite GCRCs has increased steadily, reflecting a broad range of faculty research interests. The present application contains 87 separate protocols, with involvement of faculty from the Schools of Medicine, Public Health, and Nursing at Emory, and Morehouse School of Medicine as well. We attribute expanded use of our GCRC program to a combination of promotion of clinical research by GCRC staff and faculty, availability of the Grady satellite GCRC, recruitment of faculty clinical investigators, and the NIH commitment to clinical research career support exemplified by the individual and institutional "K" series awards; Emory has both K12 and K30 programs, and many K12- and K23-supported faculty utilize the GCRCs. Emory's new Research Strategic Plan has a strong emphasis on translational and integrative multidisiplinary research, and the Emory GCRC Program (with units in both university and urban hospital settings) is expected to play a vital role in this endeavor - applying cutting edge, state of the art tools and methodologies to produce the critical new knowledge needed to advance human health.