REGIONAL BRAIN CONTROL OF LABORATORY INDUCED AGGRESSION AS ASSESSED BY FDG PET

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。冲动攻击是人格障碍患者的一个重要临床问题；然而，这是一个难以研究的行为，因为它是一个间歇性的行为。因此，有必要对人格障碍患者的冲动性攻击行为进行实验室评估。在本研究中，我们建议使用一种攻击的实验室测量方法——点减攻击范式（PSAP）来研究18FDG- PET在冲动攻击人格障碍被试和比较对照组之间脑激活模式的差异。我们建议在完成PSAP后对3名冲动性人格障碍受试者和3名非冲动性人格障碍对照受试者进行成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impulsive aggression is an important clinical problem in patients with personality disorders; however, it is a difficult behavior to study in that it is an intermittent behavior. It is, therefore, essential to develop a laboratory assessment of impulsive aggression in personality disorders. In this study we propose to use a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP) to study differences in brain activation patterns using 18FDG- PET between personality disordered subjects with impulsive aggression and comparison controls. We propose to image 3 impulsive personality disorder subjects, and 3 non-impulsive comparison subjects after completion of the PSAP.