COMPARISON OF THE EFFECTS OF SMOKED MARIJUANA AND ORAL THC: AIDS WASTING

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是比较吸食大麻和口服THC的效果。吸食大麻和口服THC对主观、认知、生理和镇痛反应的评估产生剂量相关的影响，其幅度和/或持续时间不同。 在美国，吸食大麻是最普遍的非法药物使用形式，大麻也因其潜在的药用价值而受到关注。支持者认为，吸食大麻提供：缓解化疗引起的恶心和呕吐，刺激艾滋病消耗综合征和厌食症的食欲，降低青光眼患者的眼内压，减轻疾病相关的疼痛。此外，他们认为，通过吸食大麻获得的快速起效，易于剂量滴定和多种大麻素可能比口服单一大麻素THC具有明显的优势。缺乏系统的研究比较吸食大麻和口服THC的影响，这突出了需要进行适当设计和良好对照的试验，包括检查大麻镇痛效果的试验。越来越多的证据表明大麻素与疼痛感知和镇痛有关。该协议比较，在有经验的大麻用户，两个剂量的口服THC与两个剂量的吸食大麻的认知和主观影响，镇痛和生理反应的临床相关措施。包括两种对照条件：口服氢可酮和安慰剂。包括氢可酮是因为它预计会产生相对于没有药物的许多结果指标的变化，而包括安慰剂以控制任何参与者的预期。每个参与者将完成由口服THC、NIDA提供的含3.1%THC香烟的喷烟、口服盐酸羟考酮或安慰剂的特定药物剂量定义的六种剂量条件。将使用IRB批准的电话访谈筛选潜在参与者。符合研究入选标准的受试者将接受相应的给药，并将在每个阶段进行计算机驱动测试。每次治疗期间将采集血样。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to compare the effects of smoked marijuana and oral THC. Smoked marijuana and oral THC produce dose-related effects on assessments of subjective, cognitive, physiological, and analgesic responding differing in magnitude and/or duration. Marijuana smoking is the most prevalent form of illicit drug use in the U.S. Marijuana has also gained attention for its potential medicinal value. Supporters argue that smoked marijuana offers: relief from chemotherapy-induced nausea and vomiting, stimulation of appetite for AIDS wasting syndrome and anorexia, reduction of intraocular pressure in glaucoma patients, and alleviation of disease-related pain. In addition, they suggest that the rapid onset, easy dose titration, and variety of cannabinoids available through smoked marijuana may provide a clear advantage over oral administration of a single cannabinoid, THC. The lack of systematic research comparing the effects of smoked marijuana to oral THC highlights the need for properly designed and well-controlled trials, including trials examining the analgesic efficacy of marijuana. There is growing evidence that cannabinoids are relevant to pain perception and analgesia. This protocol compares, in experienced marijuana users, two doses of oral THC with two doses of smoked marijuana on clinically relevant measures of cognitive and subjective effects, analgesia, and physiological response. Two control conditions are included: oral hydrocodone and placebo. Hydrocodone is included because it is expected to produce changes on many outcome measures relative to no medication, while placebo is included to control for any participant expectancies. Each participant will complete six dose conditions defined by a particular drug dose of oral THC, puffs from 3.1% THC-containing cigarettes provided by NIDA, oral oxycodone HCl, or placebo. Potential participants will be screened using an IRB-approved telephone interview. Participants who meet the inclusion criteria for the study will be dosed accordingly and will proceed to take computer driven testing throughout each session. Blood samples will be taken during each session.