GENETIC VARIATION IN ACUTE DRUG EFFECTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是确定非慢性咖啡因使用者对咖啡因急性反应的变异的遗传基础。我们最近发现，具有一定A2A腺苷受体基因多态性的人更有可能在急性剂量的咖啡因(300毫克柠檬酸咖啡因，相当于约150毫克咖啡因或1.8盎司咖啡)后表现出焦虑。我们现在希望通过测试低剂量和高剂量咖啡因的受试者来复制和扩展这些发现。据推测，当控制血浆咖啡因浓度时，咖啡因主观效应的变化将与腺苷受体的多态有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to determine the genetic basis of variations in acute responses to caffeine in non-chronic caffeine users. We have recently found that with a certain polymorphism of the A2A adenosine receptor gene are more likely to expreience anxiety after an acute dose of caffeine (300 mg caffeine citrate, equivalent to about 150 mg caffeine or 1 8-ounce cup of coffee). We now wish to replicate and extend these findings by testing subjects with both a lower and a higher dose of caffeine. It is hypothesized that variations in the subjective effects of caffeine will be realted to polymorphisms of the adenosine receptor, when plasma caffeine concentration is controlled.