THE ROLE OF CORTISOL IN GESTATIONAL DIABETES MELLITUS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。妊娠期糖尿病（GDM）孕妇的下丘脑-垂体-肾上腺轴（hp -a）减弱，导致总皮质醇和游离皮质醇水平升高，全天皮质醇分泌离散升高，组织对皮质醇的反应改变。假设这种功能性高皮质醇血症有助于GDM孕妇与正常糖耐量孕妇的胰岛素抵抗增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pregnant Women with gestational diabetes mellitus (GDM) will have an attenuation in their hypothalamic-pituitary-adrenal (H-P-A) axis which results in elevated total and free morning cortisol levels, discrete elevations in cortisol secretion throughout the day, and altered tissue response to cortisol. It is hypothesized that this functional hypercortisolism contributes to the increased insulin resistance seen in pregnant women with GDM versus normal glucose tolerance pregnant women.