ASSESS CHANGES IN MEMBRANE LIPID COMPOSITION ON A HIGH PROTEIN, LOW CARB DIET

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究着眼于低碳水化合物饮食和高碳水化合物饮食如何影响脂肪组织和血液细胞中的脂肪类型。我们对此很感兴趣，因为某些类型的脂肪可能会增加或降低未来患心脏病的风险。在这项研究中，我们将在一年的时间里采集血液样本，观察细胞膜，并在遵循每种饮食时分析细胞中脂肪的类型。我们还将从臀部区域提取少量脂肪，以检查脂肪组织中的脂肪酸(或脂肪)类型。这将在一年中进行4次。在开始指定的饮食之前，将采集第一个组织样本。最终的组织样本将在开始指定的饮食后一年内采集。我们还将查看食物记录，以了解每种饮食中吃的是什么类型的食物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study looking at how a low versus a high carbohydrate diet affects the type of fats in fat tissue as well as in cells in the blood. We are interested in this because certain types of fats may either increase or decrease the risk of developing heart disease in the future. In this study, we will take blood samples over the period of a year to look at the membranes of cells and analyze the types of fats in the cells as each diet is followed. We will also take a small amount of fat from the buttocks region to examine the types of fatty acids (or fats) in the fat tissue. This will be done 4 different times throughout the year. The first sample of tissue will be taken before the assigned diet is started. The final sample of tissue will be taken 1 year after starting the assigned diet. We will also look at food records to see what types of foods are being eaten on each diet.