ESTIMATING HUMAN ZINC PHYSIOLOGICAL ZINC REQUIREMENTS: TESTING A NEW CONCEPT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。食品和营养委员会最近采纳了一个关于人体如何调节锌的新概念这导致了对膳食锌需求量的估计大幅增加。该提案的长期目标是实现人体锌需求的准确计算-估计的平均个人膳食需求（ear）和推荐膳食允许量（rda）。本提案将专门研究影响全身锌稳态的各种因素之间的相互关系，并将特别研究从饮食中吸收的锌量与从粪便和尿液中消除的锌量之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Food and Nutrition Board recently adopted what was essentially a new concept of how the human body regulates zinc that resulted in a very major increase in estimates of dietary zinc requirements. The long-term goal of this proposal is to achieve accurate calculations of human zinc requirements - estimated average individual dietary requirements (EARs) and recommended dietary allowances (RDAs). This proposal will specifically examine the interrelationships between various factors affecting whole body zinc homeostasis, and will particularly examine the relationship between the amount of zinc absorbed from the diet and the amount of zinc eliminated in feces and urine.