EFFECT OF DIETARY FAT ON SYMPATHETIC NERVE ACTIVITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究将阐明摄食交感神经激活的机制。已知胰岛素在碳水化合物给药后诱导交感神经系统激活，但在脂肪摄入后不增加。因此，脂肪负荷后交感神经活动（SNA）的增加表明胰岛素以外的介质的参与。这些研究人员建议研究精瘦和肥胖受试者对口服脂肪、碳水化合物或水的急性肌肉和皮肤SNA反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will clarify the mechanisms of sympathoactivation to meal ingestion. Insulin is known to induce sympathetic nervous system activation after carbohydrate administration but is not increased after fat ingestion. Thus, increases in sympathetic nerve activity (SNA) after a fat load would suggest the involvement of mediators other than insulin. These investigators propose to study the acute muscle and skin SNA response to oral fat, carbohydrate or water in lean and obese subjects.