TYPE II DIABETES IN ADOLESCENTS, COGNITION, AND THE BRAIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。关于青少年2型糖尿病患者是否存在认知功能障碍的信息有限。有证据支持患有1型和2型糖尿病的成年人存在认知功能障碍。这一群体可能比青少年患病的时间要长得多。有一些证据表明1型糖尿病儿童存在认知功能障碍，但2型糖尿病儿童没有。在这项研究中，在儿科内分泌诊所接受肥胖症评估和治疗的青少年患者将被评估为1)存在2型糖尿病，2)仅有胰岛素抵抗(IR)且糖耐量正常，以及3)没有IR或糖尿病。然后他们将被登记参加一项研究，该研究将使用一系列神经心理测试来评估糖尿病患者潜在的认知缺陷。最后，他们将接受脑部磁共振成像(DT-MRI)，寻找特定区域的髓鞘形成和大小的差异。主要的假设是，患有糖尿病的青少年的神经心理评分会更低。他们还将探索IR、神经精神测试结果和MRI变量之间的相关性。将有50名患者入选。这项初步研究将为随后的更大规模的研究提供初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is limited information regarding the presence of cognitive dysfunction in adolescents with type 2 diabetes. There is evidence provided to support the presence of cognitive dysfunction in adults with both type 1 and 2 diabetes. This group has probably had disease for considerably longer than the adolescents. There is some evidence of cognitive dysfunction in children with type 1 diabetes but not those with type 2. In this study, adolescent patients seen in the pediatric endocrine clinic for evaluation and treatment of their obesity will be assessed for 1) the presence of type 2 diabetes, 2) insulin resistance (IR) alone with normal glucose tolerance, and 3) the absence of IR or diabetes. They will then be enrolled into a study that will evaluate potential cognitive defects in those with diabetes using a battery of neuropsychological tests. Finally, they will receive a brain MRI (DT-MRI), looking for differences in myelination and size, in specific regions outlined. The main hypothesis is that there will be lower neuropsychologic scores in adolescents with diabetes. They will also explore correlations between IR, neuropsychiatric test results and MRI variables. Fifty patients are to be enrolled. This pilot study would provide initial data for a subsequent larger study.