CEREBRAL RESPONSES TO INSULIN-INDUCED HYPOGLYCEMIA-AIM 4

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目的总体目标是确定胰岛素对神经元激活的影响。我们打算检验胰岛素对神经元激活的影响不依赖于葡萄糖的假设。在这个实验中，我们将检查在正常血糖钳夹期间血清胰岛素浓度被抑制或维持在高生理范围的条件下作为测量的ERP的神经元活化。将在视觉和记忆任务期间测量ERP。GCRC的作用是协助进行正常血糖钳夹试验，并在研究完成时为受试者提供膳食。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to determine the effect of insulin on neuronal activation. We intend to test the hypothesis that insulin has effects independent of glucose on neuronal activation. In this experiment we will examine neuronal activation as measured ERPs under conditions in which serum insulin concentrations are suppressed or maintained at a high physiological range during a euglycemic clamp. ERPs will be measured during a visual and a memory task. The role of the GCRC will be to assist with the euglycemic clamp and to provide subjects with a meal at the completion of the study.