BEYOND RASS STUDY (B-RASS)-AN EXTENSION OF RENIN ANGIOTENSIN SYSTEM STUDY (RASS)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。具体目标1：随访285例完成5年RASS的1型DM患者队列，其中三分之一接受ACEi治疗，三分之一接受ARB治疗，三分之一接受安慰剂治疗，随访10年，每年测量一次白蛋白排泄率（AER）、血压（BP），每两年测量一次肾小球滤过率（GFR）。具体目标二：对完成5年RASS的285例1型糖尿病患者队列再随访10年，并对眼底照片进行3次间隔评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: To follow the cohort of 285 patients with type 1 DM completing the 5-year RASS, one-third of whom were on ACEi, one-third on ARB, and one-third on placebo, for a further 10 years with annual measurements of albumin excretion rate (AER), blood pressure (BP) and bi-annual measurement of glomerular filtration rate (GFR). Specific Aim 2: To follow the cohort of 285 patients with type 1 DM completing the 5-year RASS for a further 10 years with 3 interval assessments of fundus photographs.