DOPAMINERGIC FUNCTION IN YOUNG CANNABIS ABUSERS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项R21探索性/发展赠款中提出的研究将比较15名18-21岁的受试者，这些受试者在青春期有长期吸食大麻的历史(吸食大麻的持续时间必须在18岁之前一年以上)，并与15名年龄和性别匹配的健康受试者一起接受住院康复计划(Aurora Concept，Inc.)。将测量区域葡萄糖代谢(用[18F]-FDG和PET评估)和多巴胺D2受体可用性(用[11C]-raclopide和PET评估)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study proposed in this R21 exploratory/developmental grant will compare fifteen 18-21 year old subjects with a history of prolonged cannabis exposure in adolescence (duration of cannabis use must be more than one year before age 18) and admitted to a residential rehabilitation program (Aurora Concept, Incorporated), with fifteen age- and sex-matched healthy subjects. Regional glucose metabolism (assessed with [18F]-FDG and PET) and dopamine D2 receptor availability (assessed with [11C]-raclopride and PET) will be measured.