ROLE OF PROSTAGLANDINS IN AUTONOMIC/CARDIOVASCULAR CONTROL IN HUMANS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在这个项目中，研究人员计划确定内源性前列腺素在静息和生理应激时对自主神经和心血管调节的作用。此外，他们还将研究这些影响是否会随着年龄的增长而改变。研究人员假设，前列腺素能增强压力感受性反射的敏感性，抑制交感神经流出，并以一种年龄依赖的方式改变骨骼肌对生理应激源的血流反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, the investigators plan to determine the role of endogenous prostaglandins on autonomic and cardiovascular regulation both at rest and in response to physiological stressors. In addition, they will study if these effects are altered with age. The investigators hypothesize that prostaglandins tonically augment baroreflex sensitivity, inhibit sympathetic outflow and alter the skeletal muscle blood flow responses to physiological stressors in an age-dependent manner.