MECHANO-PHYSIOLOGICAL APPROACH: ANORECTAL FUNCTION & CLASS OF DEFECATORY DISORDE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究的目的是研究肠道的运动和直肠和腹部肌肉的压力变化，以了解排便（排便）的生理学。便秘是一种非常常见的情况，16-20%的受访者报告说。目前用于评估便秘的方法并不令人满意。更好地了解这一过程可能有助于设计更好的治疗方法和诊断测试。这项研究包括两项测试，肛门直肠测压和排便造影术，这两项都得到了FDA的批准，并被用作标准的诊断测试。唯一新增的部分是同时进行两项测试，这将使我们能够将压力（测压）和透视图像的记录结合在录像带上，并详细分析某些肌肉群在排便过程中的参与情况。这项研究将在健康志愿者和由医生推荐进行排便造影（研究排便过程的测试）的患者中进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is study the movement of the intestines and pressure changes in the rectum and abdominal muscles in order to understand the physiology of defecation (making a bowel movement). Constipation is a very common condition, reported by 16-20% of people surveyed. The methods currently used for the assessment of the constipation are not satisfactory. Better understanding of the process may help to design better treatments and diagnostic tests. The study involves two tests, anorectal manometry and defecography, which are both approved by FDA and used as standard diagnostic tests. The only new, additional part would be the performance of the two tests simultaneously which will allow us to combine recordings of the pressure (manometry) and fluoroscopy images on videotape and to analyze the participation of the certain groups of muscles in the process of defecation in detail. The study will be performed in healthy volunteers and patients referred for defecography (the test to study the process of defecation) by their physicians.