WOMEN RESILIENCE TO TRAUMA: FMRI STUDY OF EMOTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这个项目的主要目标是为拨款提案获得试点数据。该基金的目标是了解经历过性创伤或亲密伴侣暴力的女性的情绪区域大脑控制。具体来说，该项目将比较那些在创伤暴露后表现出适应力的女性（通过在工作、人际关系和生活享受方面的功能维持来证明）和那些表现出功能障碍并发展为创伤后应激障碍的女性。fMRI BOLD反应将用于探索对极端压力负面后果的恢复能力是否与杏仁核减少和内侧前额叶皮质功能增强有关，这些功能在fMRI成像任务中被设计用于评估这些大脑结构。我们建议在fMRI中使用四个任务。1)认知重新评估任务已被证明可以激活前额皮质。在这项任务中，研究对象被要求观看旨在引起情绪中立、消极和积极反应的图片。他们还将被要求在磁铁中增强和抑制这些情绪。2)我们还将使用一项任务，让受试者看到不同强度的情绪面孔，向他们展示恐惧、愤怒和中性的面孔。这项任务已经被证明可以激活杏仁核。3)我们将采用奖励激励任务，让受试者在不同的条件下玩电脑游戏，有可能赢或输少量的钱。4)最后，他们将在一项任务中使用功能磁共振成像进行研究。在这项任务中，他们将被告知，在观看特定图像时，他们将受到不舒服但不是非常痛苦的电击，而在其他条件下，他们将是“安全的”。实际上，不会有电击。最后，我们将探讨与积极情绪/乐观、认知灵活性（包括积极重新评价的能力）、道德指南针（包括灵性和宗教依恋的测量）、社会支持和积极应对等领域的功能弹性相关的社会心理因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principal goal of this project is obtain pilot data for a grant proposal. The goal of the grant is to understand the regional brain control of emotion in women who have experienced sexual trauma or intimate partner violence. Specifically, the project will compare women who demonstrate resiliency after traumatic exposure (as evidenced by the maintenance of function in the domains of work, interpersonal relationships and enjoyment of life) to those who show functional impairment and develop PTSD. fMRI BOLD response will be used to explore whether resilience to the negative consequences of extreme stress will be related to reduced amygdala and enhanced medial prefrontal cortex function in response to fMRI imaging tasks designed to evaluate these brain structures. We propose to use four tasks during fMRI. 1) A cognitive reappraisal task has been shown to activate the prefrontal cortex. In this task, subjects are asked to view pictures designed to elicit emotionally neutral, negative and positive responses. They will also be asked to enhance and suppress those emotions while in the magnet. 2) We will also be using a task exposing subjects to different intensities of emotional faces, showing them fearful, angry and neutral faces. This task has been shown to activate the amygdala. 3) We will employ a reward incentive task in which subjects play a computer game under different conditions with the potential to win or lose small amounts of money. 4) Lastly, they will be studied with fMRI during a task in which they will be told that they will be given an uncomfortable but not extremely painful electric shock, while viewing specific images, while under other conditions they will be "safe'. In actuality, no shock will be delivered. Finally we will explore psychosocial factors associated with functional resilience in the domains of positive emotions/optimism, Cognitive flexibility (including the capacity for positive reappraisal), moral compass (including measures of spirituality and attachment to religion), social support and active coping.