EFFECTS OF HIV ON BONE MASS IN THE ELDERLY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。该研究的具体目的是比较一组老年HIV阳性女性和男性与匹配的HIV阴性对照，以确定骨矿物质密度和骨转换生化标志物的差异。 艾滋病毒感染是一个重大的全球性公共卫生问题。美国的患者可以获得高效抗逆转录病毒疗法（HAART），近年来，这种疗法降低了发病率并延长了寿命。然而，这些药物与显著的代谢紊乱如葡萄糖耐受不良、高脂血症和脂肪代谢障碍相关。最初的临床和实验室数据表明，HIV感染者无论是否接受HAART治疗，骨质疏松症的风险都增加。与此同时，最近HIV患者的平均年龄显著增加，其中代谢紊乱，包括对骨骼的可能影响，仍然没有得到表征。因此，本研究的长期目标将是检查HIV对老年人群骨量的影响。核心假设是，艾滋病毒阳性老年妇女和男子的骨量低于匹配的艾滋病毒阴性对照。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aim of the study will be to compare a cohort of elderly HIV positive females and males with matched HIV-negative controls to determine differences in bone mineral density and biochemical markers of bone turnover. HIV infection is a major worldwide public health problem. Patients in the United States have access to highly active antiretroviral therapy (HAART) that has, in recent years, decreased morbidity and prolonged life. However, these agents are associated with significant metabolic disturbances such as glucose intolerance, hyperlipidemia and lipodystrophy. Initial clinical and laboratory data suggest that patients with HIV with or without HAART therapy are at increased risk of osteoporosis. In parallel, there has been a notable recent increase in the mean age of HIV pateints in whom metabolic disturbances, including possible effects on bone, remain uncharacterized. Therefore, the long-term goal of this study will be to examine the effects of HIV on bone mass in the elderly population. The central hypothesis is that HIV positive elderly women and men have lower bone mass than matched HIV negative controls.