BIOMARKERS OF BRAIN PATHOLOGY IN CHILDREN WITH TRAUMATIC BRAIN INJURY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。创伤性脑损伤每年导致儿童死亡和致残的人数超过任何其他原因(Duhaime和Raghupari，1999年)，是导致儿童和年轻人长期残疾的主要原因(国立卫生研究院，1999年)。尽管这是一个紧迫的健康问题，但我们对与人类急性脑损伤相关的病理机制事件的了解仍然相当有限，而且在这种临床环境下，还没有针对儿童或成人的有效治疗方法。这项在患有脑外伤的儿童中进行的研究旨在确定选定的血液和脊髓液生物标记物浓度以及高级神经监测参数与患者预后之间的关系。基于这一分析，可能会识别出潜在有用的生物标志物和神经监测参数。后者将有几个重要的临床应用：它可以使我们1)根据颅脑损伤的严重程度对患者进行分层；2)更好地监测脑损伤引起的病理和康复的进展；3)指导治疗；4)监测治疗/干预的效果；以及5)更准确地预测儿童创伤性脑损伤后的预后。准确的患者分层和预测结果的有效方法对于随后在这一患者群体中进行临床试验至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury (TBI) kills and disables more children each year than any other cause (Duhaime and Raghupathi 1999) and is the leading cause of long-term disability in children and young adults (National Institutes of Health, 1999). Despite the fact that it is a pressing health issue, our understanding of the pathomechanistic events associated with acute brain injury in humans remains quite limited, and there are no proven therapies for children or adults in this clinical setting. This study in children suffering TBI is designed to characterize the association between the concentrations of selected blood and spinal fluid biomarkers and advanced neuro-monitoring parameters with patient outcome. Based on that analysis, potentially useful biomarkers and neuro-monitoring parameters may be identified. The latter will have several important clinical applications: it may allow us 1) to stratify patients by the severity of their TBI; 2) to better monitor the progression of brain injury-induced pathology and recovery; 3) to guide therapy; 4) to monitor the effects of therapy/intervention; and 5) to predict outcome more accurately after traumatic brain injury in children. Accurate patient stratification and valid methods of predicting outcome are vital to the subsequent conduct of clinical trials in this patient population.