COBRE: UDE CORE INFRASTRUCTURE: SHARED FACILITIES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。科布雷支持4个核心设施的运营，这些设施的范围和性质相当不同。其中两个位于特拉华州生物技术研究所(DBI)，即。蛋白质生产设施和生物成像核心，并在由DBI运营的更大一组核心中进行管理，吴博士和切姆梅克分别担任经理。蛋白质生产设施由最初的Cobre赠款提供资金，主要由目前的Cobre提供支持，但生物成像核心是由DBI管理的更大的企业，Cobre提供了相对较小的一部分。X射线结晶学核心位于校园内唯一的大分子结晶学家Brian Bahnson博士的实验室，并得到Cobre的支持，以表彰通过那里的设施寻找结构信息的众多研究人员。工程学院生物技术核心设施是一个相当廉价的运作，由Lenhoff博士和Robinson博士在博士后和研究生的协助下在学院内部进行本地管理。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The COBRE supports the operation of 4 core facilties that are quite diverse in their scope and nature. Two are located at the Delaware Biotechnology Institute (DBI), viz. the Protein Production Facility and the Bioimaging Core, and are administered within the larger set of cores operated by DBI, with Drs. Wu and Czymmek as the respective managers. The Protein Production Facility was funded by the original COBRE grant and is supported primarily by the present COBRE, but the Bioimaging Core is a much larger enterprise administered by DBI, of which the COBRE provides a relatively small fraction. The X-ray Crystallography Core is located in the labs of Dr. Brian Bahnson, the only macromolecular crystallographer on campus, and is supported by COBRE in recognition of the numerous researchers seeking structural information via the facilities there. The College of Engineering Biotechnology Core Facility is a fairly inexpensive operation that is managed locally within the College by Dr. Lenhoff and Robinson with the assistance of postdocs and graduate students.