COBRE in Sensory Neuroscience

超出空间 提供了 最初的COBRE拨款建立了感觉神经科学研究中心（SNRC）， 西弗吉尼亚大学独立调查员的核心。这种COBRE支持刺激了机构 承诺新的终身制工资线和为SNRC扩建建设现代化实验室空间 并使SNRC调查人员能够获得R01资金。我们请求COBRE第二阶段的支持， 发展自我维持的研究事业，从而提高我们机构的研究能力。 我们提出了四个具体目标。 目标1是获得足够数量的独立资助的科学家。我们已经从4名发展到10名西弗吉尼亚大学的调查员 在目前的融资期内。在这项申请中，其中5名科学家提出了新的项目，以帮助过渡 R01独立基金在拟议的拨款支持下，我们将通过招聘进一步扩大到14名教职员工 建立科学家，特别是临床研究人员，以扩大我们的研究机制的感觉障碍。 目标2是通过促进教师之间的新合作来促进对感觉系统的理解， 将新的调查人员纳入中心。最近和预计的招聘扩大了我们工作的集体范围 并增加新的技术专长，为科学互动提供独特的机会。 目标3是通过扩大核心设施来扩大机构研究基础设施。请求提供支助， SNRC研究和管理活动的核心设施，管理这些核心的人员，以及部分支持 对于SNRC研究工作至关重要的机构核心设施。 目标4是使SNRC过渡到独立地位。通过进一步的COBRE支持，我们将获得强大的基础， R01资助支持研究核心和计划项目赠款的申请。我们的健康科学中心 实施了一项战略研究计划，为基础设施和教师招聘提供资源， 合格的研究生的数量在我们的实验室培训，并支持我们的研究计划。 五个研究项目包括四个感觉系统（听觉，嗅觉，体感和视觉）， 提出了这些项目反映了SNRC的多学科方法，其中包括比较 感官形态和多层次分析（分子到系统），从无脊椎动物 通过人类。

EXCEED THE SPACE PROVIDED. The initial COBRE grant established the Sensory Neuroscience Research Center (SNRC) with a multidisciplinary nucleus of independent investigators at West Virginia University. This COBRE support stimulated institutional commitments for new tenure-track salary lines and the construction of modern laboratory space for SNRC expansion and enabled SNRC investigators to obtain R01 funding. We request a second phase of COBRE support to complete the development of a self-sustaining research enterprise, and thereby increase the research capacity of our institution. We propose 4 specific aims. Aim 1 is to achieve a critical mass of independently funded scientists. We have grown from 4 to 10 WVU investigators during the current funding period. In this application, 5 of these scientists have proposed new projects to aid transition to independent R01 funding. With proposed grant support we will further expand to 14 faculty members by recruiting established scientists, especially clinician investigators to broaden our studies of mechanisms of sensory disorders. Aim 2 is to advance understanding of sensory systems by fostering new collaborations among faculty, thereby integrating new investigators into the Center. Recent and projected recruits extend the collective scope of our work and add new technical expertise that underlies unique opportunities for scientific interaction. Aim 3 is to expand institutional research infrastructure through expansion of core facilities. Support is requested for SNRC core facilities for research and administrative activities, personnel to administer these cores, and partial support for institutional core facilities that are central to SNRC research efforts. Aim 4 is to transition the SNRC to independent status. With further COBRE support, we will obtain a strong base of R01 funding that underpins applications for research core and program project grants. Our Health Sciences Center has implemented a strategic research plan to provide resources for infrastructure and faculty recruitment and increase the number of qualified graduate students to train in our laboratories and support our research programs. Five research projects encompassing four sensory systems (auditory, olfactory, somatosensory, and visual) are proposed. These projects reflect the multidisciplinary approach of SNRC, which includes the comparison across sensory modalities and multiple levels of analysis (molecular to systems), in species ranging from invertebrates through humans.