DEVELOPMENTAL CHANGES IN CORPUS LUTEUM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。Telleria博士实验室的主要研究领域是类固醇和肽激素控制卵巢细胞功能、存活和生理性死亡（凋亡）的分子机制。在体内，离体和体外实验方法结合最先进的技术来研究细胞凋亡和基因表达。最终目标是了解卵巢细胞死亡的机制，以便能够：1)在黄体功能障碍和黄体功能不全引起的不孕情况下重建功能，其中主要问题是黄体酮分泌量或持续时间不足，导致反复妊娠丢失；二)加速卵巢癌的细胞死亡，卵巢癌是妇女癌症死亡的第四大常见原因，也是妇科恶性肿瘤死亡的主要原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major area of research undertaken in Dr. Telleria's laboratory deals with the molecular mechanisms by which steroid and peptide hormones control function, survival and physiological death (apoptosis) of ovarian cells. In vivo, ex-vivo and in-vitro experimental approaches are used combined with state-of-the-art techniques for the study of apoptosis and gene expression. The ultimate goal is to understand the mechanisms of ovarian cell death to be able to: i) reestablish function in cases of infertility caused by luteal dysfunction and corpus luteum inadequacy, in which the primary problem is the insufficient quantity or duration of progesterone secretion that leads to repetitive pregnancy losses; and ii) accelerate cell death in the case of ovarian cancer, which is the fourth most frequent cause of cancer death among women and the leading cause of death from gynecological malignancies.