Northern Plains Center for Behavioral Research Translation

描述（由申请人提供）：这个提议的北方平原研究翻译中心（NPCRT）的目标是在北达科他大学创建一个多学科，临床和转化研究的综合项目，为该地区的高危农村人口服务。NPCRT的目标是制定、测试和传播干预措施和最佳做法，以解决通常可预防的行为介导的生理障碍，如肥胖和糖尿病，神经退行性疾病，如阿尔茨海默病和帕金森病，以及行为障碍，如抑郁和自杀。这些疾病不成比例地影响到我们区域处境最不利的人——美洲印第安人、农村贫困老人、妇女和儿童。NPCRT将通过提供临床和转化科学的研究生学位，并提供研究培训，为研究人员在职业发展的各个阶段提供服务。该CTSA项目的具体目标是：1)制定计划，将临床和转化研究发展为联合国大学的一门学科；2)科研、教育、培训和职业发展规划；3)需求分析确定

DESCRIPTION (provided by applicant): The goal of this proposed Northern Plains Center for Research Translation (NPCRT) is to create a multidisciplinary, integrated program of clinical and translational research at the University of North Dakota that serves at-risk rural populations across the region. The NPCRT's objective is to develop, test, and disseminate interventions and best practices that address often-preventable behaviorally mediated physiologic disorders such as obesity and diabetes, neuro-degenerative disorders such as Alzheimer's and Parkinson's, and behavioral disorders such as depression and suicide. These diseases disproportionately affect the most disadvantaged people in our region-American Indians, the elderly rural poor, women and children. The NPCRT will serve investigators at all stages of career development by offering graduate degrees in the clinical and translational sciences, and provide research training. The specific aims of this CTSA project are to create: 1) plans for the development of clinical and translational research as a discipline at UNO; 2) plans for research education, training, and career development; 3) a needs analysis to determine the expertise and resources that the CTSA will develop and offer; 4) a plan for CTSA organization, administration, governance, and evaluation; 5) a plan for CTSA senior leadership selection; 6) a plan to assure adequate space and facilities; 7) plans for firm commitments for local funding and institutional support; 8) a plan to assure scientific quality; and 9) a plan to develop collaborations and dissemination. Our transformational vision is to plan an innovative, distributed, rural CTSA model driven by the health needs of our people. Obesity has skyrocketed-62% of ND adults are now overweight or obese. Type 2 diabetes prevalence in ND jumped 72% from 1994 to 2003. Neurodegenerative disorders (Alzheimer's and Parkinson's) are increasingly prevalent. American Indian youth in ND die by suicide at a rate 429% higher than that for young whites. Development and dissemination of new interventions and best practices is needed to reduce morbidity and mortality from these diseases. We must address these health care needs, as well as the disparities in health status that exist between these vulnerable groups and others, thus our appeal for funding to plan a Northern Plains Center for Research Translation.