COBRE: U KS: CORE A: ADMINISTRATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。拟议COBRE计划的总体目标是建立一个多学科研究中心，专注于使用最佳实验策略来探测目标蛋白质的结构和功能特性。该中心将为堪萨斯大学劳伦斯分校（KU-L）、堪萨斯城堪萨斯大学医学中心（KUMC）、曼哈顿堪萨斯州立大学（KSU）和威奇托州立大学（WSU）的几位从事蛋白质化学和生物学界面工作的初级教师提供密集的指导和一流的研究环境，以提高他们的竞争力。参与课程的教师来自不同的院系，但他们都对理解特定蛋白质的结构与其在细胞生物学中的功能角色之间的关系有着浓厚的兴趣。从质谱学、蛋白质晶体学到微生物发病机理和细胞分化调控，由初级教师和高级指导教师代表的专业知识涵盖了广泛的领域。然而，所有参与者都有一个强烈的愿望，即应用有效的现代技术和实验策略来表征重要蛋白质。我们的具体目标是：目标1。建立一个卓越的蛋白质结构和功能生物医学研究中心，与其他区域在蛋白质组学、蛋白质化学和生物学方面的努力协同作用。目标2。在四个机构中组织一个由美国国立卫生研究院资助的知名教师组成的核心团队，他们将作为蛋白质结构和功能领域新聘用和即将聘用的教师的导师，并支持初级教师的5¿6个独立研究项目，从生物学和化学的角度以综合的多学科方式解决蛋白质结构和功能方面的重大问题。在5年的时间里，COBRE项目将帮助至少15名新教师在蛋白质结构和功能方面开发具有高度竞争力的研究项目。目标3。通过建立科学核心，为蛋白质结构和功能研究提供专业知识和仪器，加强蛋白质结构和功能研究的整体基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the proposed COBRE program is to establish a multidisciplinary research center focused on the use of the best experimental strategies available to probe the structural and functional properties of targeted proteins. The Center will provide intensive mentoring and superb research environments to enhance the competitiveness of several junior faculty working at the interface of protein chemistry and biology at University of Kansas in Lawrence (KU-L), University of Kansas Medical Center in Kansas City (KUMC), Kansas State University in Manhattan (KSU), and Wichita State University in Wichita (WSU). Participating faculty are based in a variety of departments, but they all share a strong interest in understanding the relationship between the structure of a specific protein and its functional role in the biology of the cell. The expertise represented by both the junior faculty participants and the senior mentoring faculty spans a broad range from mass spectrometry and protein crystallography to microbial pathogenesis and regulation of cell differentiation. However, all participants are united by a strong desire to apply effective modern technologies and experimental strategies to the characterization of important proteins. Our specific aims are: Aim 1. To establish a Center of Biomedical Research Excellence in Protein Structure and Function that will synergize with other regional efforts in proteomics and protein chemistry and biology. Aim 2. To organize a core of well-established, NIH-funded faculty members across the four institutions who will serve as mentors for recently hired and to-be-hired faculty in the area of protein structure and function, and to support 5 ¿ 6 independent research programs of junior faculty addressing significant problems in protein structure and function from a biological as well as chemical perspective in an integrated, multidisciplinary way. Over the 5-year period the COBRE program will assist at least 15 new faculty in developing highly competitive research programs in protein structure and function. Aim 3. To enhance the overall infrastructure for state-of-the-art research in protein structure and function through establishment of scientific cores that provides expertise and instrumentation in support of research in protein structure and function.