COBRE: UNE MED CTR: CORE B: MOUSE GENOME ENGINEERING

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项COBRE提案的一个目标是建立三角UNMC-Creighton-Boys Town NRH作为公认的神经感官发展卓越研究中心。随着这三个机构对人类卫生保健的承诺，小鼠将成为未来生物医学研究这一主题的首要模式生物。因此，小鼠核心的存在和可用性不仅通过现场建立相关小鼠模型使最初的COBRE调查员受益，而且在最初的COBRE调查员轮换和新调查员加入后，将成为必不可少的招聘工具。我们预计这样的招募也将集中在老鼠身上，使用基因改造的老鼠来推进他们的研究。特别是，经验有限的初级研究人员将从Mouse Core的支持服务中受益匪浅。此外，我们期望本提案的几个项目的表达谱实验将产生值得为各自基因产生新的转基因和敲除小鼠模型的结果，以研究它们在神经感觉发育中的功能。因此，我们相信，鼠标核心的可用性将大大提高COBRE提案所促进的校外资金新申请的竞争力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One goal of this COBRE proposal is to establish the triangle UNMC-Creighton-Boys Town NRH as a recognized Center of Research Excellence in Neurosensory Development. With the commitment of all three institutions to human health care, the mouse will be the paramount model organism for future biomedical research on this topic. The presence and availability of a Mouse Core will, therefore, not only benefit the initial COBRE Investigators through the on-site establishment of the pertinent mouse models, but will serve as an essential recruiting tool once the initial COBRE Investigators will rotate off and new Investigators will be brought aboard. We anticipate that such recruits will also focus on the mouse, use genetically manipulated mice to advance their research. In particular, junior Investigators with limited experience with mice would greatly benefit from Mouse Core support services. Furthermore, we expect that the expression profiling experiments of several projects of this proposal will yield results that merit the generation of new transgenic and knockout mouse models for the respective genes in order to study their function in neurosensory development. We are therefore convinced that the availability of a Mouse Core will significantly enhance the competitiveness of new applications for extramural funding that are fostered by this COBRE proposal.