Clinical Relevance of Mismatch Repair in Ovarian Cancer

一个集研究、教育和教学为一体的五年制课程将为申请者提供一份优秀的 有机会获得和完善研究方法方面的技能，包括设计、实施和 分析高质量的基于流行病学的癌症遗传学研究，在专家指导下 这一领域的科学家。授课培训的重点领域是：1)遗传流行病学，2)研究 设计和统计方法，3)基于实验室的分子分析，以及4)卵巢肿瘤生物学， 目标是将这些知识应用于翻译研究。培训和研究目标将是 通过正式培训(课程作业)、指导(通过下列人员的导师/顾问)来完成 遗传流行病学、统计学、分子遗传学和卵巢肿瘤发生方面的专家)，以及实用 经验(通过开展研究性学习)。这个特殊的项目将解决所有学习问题 申请人的目标通过分子、病理学和统计学的各种成分 分析，并将向她提供在这些具体领域概述的实践经验。通过 提供有意义的科学数据，该项目本身将加强与 卵巢癌遗传易感性的实验室标记物研究。它将建立在现有知识的基础上 破译与错配修复相关的病因学、预测预后和治疗反应 卵巢肿瘤发生的途径，并形成进一步的翻译研究的基础。帕尔博士的长期 目标是开发一个基于流行病学的癌症遗传学研究计划，利用 跨学科方法。这一目标将通过在学术健康学院担任教职来实现。 科学中心。赞助机构的资源是优秀的，将促进成功的， 高效完成所述总体目标。这些目标的实现将提供 作为一名成功的、致力于学术研究的独立调查员的职业生涯所需的专业知识。

A 5-year program integrating research, education, and teaching will provide the applicant with an excellent opportunity for the acquisition and refinement of skills in research methods that include design, conduct and analysis of high-quality epidemiologically-based cancer genetics research, under expert guidance of scientists in the field. Specific areas of focus for didactic training will be: 1) genetic epidemiology, 2) study design and statistical methodology, 3) laboratory-based molecular analyses, and 4) ovarian tumor biology, with the goal of applying this knowledge in translational research. The training and research objectives will be accomplished through formal training (course work), mentorship (through mentors/consultants who are experts in genetic epidemiology, statistics, molecular genetics and ovarian tumorigenesis), and practical experience (through conducting proposed research study). This particular project will address all learning objectives of the applicant through the various components of molecular, pathological and statistical analyses, and will provide her with the practical experience in these specific areas outlined. Through the provision of meaningful scientific data, the project itself will augment existing research associated with the genetics of ovarian cancer susceptibility with laboratory markers. It will build upon current knowledge in deciphering etiology and predicting prognosis and treatment response as it relates to the mismatch repair pathway to ovarian tumorigenesis, and form the basis of further translational studies. Dr. Pal's long-term goal is to develop a program of research in epidemiologically-based cancer genetics research utilizing an interdisciplinary approach. This goal will be accomplished by being in a faculty role at an academic health science center. The resources of the sponsoring institution are excellent and will facilitate the successful, efficient completion of the overall objectives outlined. The achievement of these goals will provide the expertise needed for a career as a successful, independent investigator committed to academic research.