Helminth secretomes: from vaccines to novel anti-inflammatory biologics

发展中国家有数十亿人感染了寄生虫，但工业化国家已经根除了这些寄生虫。人类与蠕虫共同进化，所以最近它们的消失剥夺了我们控制炎症所需的信号。我的研究重点是蠕虫分子，这些分子可用于(1)开发疫苗以对抗发展中国家的这些寄生虫感染，以及(2)作为工业化国家使用的抗炎疗法的新平台。

Billions of people in developing countries are infected with parasitic worms, but they have been eradicated from industrialised nations. Humans co-evolved with worms, so their recent removal has deprived us of signals required to keep inflammation in check. My research focuses on worm molecules that can be used to (1) develop vaccines to combat these parasitic infections in developing countries, and (2) as a novel platform of anti-inflammatory therapeutics for use in industrialised nations.