DESIGN & DEVELOPMENT OF NEW MALDI ION TRAP MASS SPECTROMETERS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。离子阱质谱仪（Finnigan）最初设计为仅与电喷雾电离源一起操作，经修改后与MALDI离子源一起操作。我们将继续评估和完善这些仪器在MALDI模式下的性能。性能特征，如样品分析的灵敏度和速度被确定为是优秀的，新的配置被发现是极好的解决具有挑战性的生物分析问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ion trap mass spectrometers (Finnigan) originally designed to operate only with an electrospray ionization source were modified to operate with MALDI ion sources. We continue to evaluate and refine the performance of these instruments used in the MALDI mode. Performance characteristics such a sensitivity and speed of sample analysis were determined to be excellent and the new configurations were found to be superb for solving challenging bioanalystical problems.