Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study

使用阿替普酶溶栓治疗中风是最有效的治疗方法之一，但目前只有5%的中风病例使用。一个主要的障碍是缺乏工具来确定谁将从治疗中受益，或者谁可能发生重大不良事件。在这项研究中，我们将基于临床数据、先进的CT成像和血液生物标志物制定临床决策规则，以帮助识别哪些人将受益，哪些人可能出血，以鼓励这种治疗方法在急性中风中更广泛地使用。

Thrombolysis using alteplase is one of the most effective treatments for stroke but is currently used in only 5% of stroke cases. A major barrier is a lack of tools to identify who will benefit from treatment, or who might have a major adverse event. In this study we will develop a clinical decision rule based on clinical data, advanced CT imaging, and blood biomarkers to help identify those who will benefit and those likely to bleed, to encourage wider use of this treatment in acute stroke.