CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。德克萨斯大学休斯顿健康科学中心（UTHSC-H）提议在德克萨斯州休斯顿的德克萨斯医学中心（TMC）建立临床和转化科学中心（CCTS）。参与CCTS的教师和学员将包括来自UTHSC-H组成学位授予学院的教师和学员，包括其医学院、公共卫生学院、生物医学科学研究生院、健康信息科学学院、护理学院、牙科学院和分子医学研究所（IMM），以及来自UT md安德森癌症中心（MDACC）的合作教师/设施，该中心也位于TMC。CCTS的学术“家”将位于新装修的11,422平方英尺的CCTS指定空间内，该空间位于UTH医学院，与纪念赫尔曼医院（MHH）相连，并作为其合作伙伴和主要教学医院。CCTS“家”将管理CCTS的所有方面，为教师和学员提供空间和资源，以及研究设计、生物统计学、监管问题、伦理和生物信息学方面的专业知识，为试点和可行性研究提供资金，为临床和转化教师和学员提供资源和保护时间，以及与各个社区和行业的互动/合作。对于参与者和临床相互作用资源（PCIR）， CCTS将包括位于MHH的UTHSC-H一般临床研究中心（GCRC），位于德克萨斯州布朗斯维尔的卫星UTHSC-H GCRC，以及MDACC临床和转化研究中心的部分内容，以提高研究生产力和效率。在其教育部分，CCTS将部分纳入目前的临床研究和循证医学中心，该中心已经开发并目前提供正式课程，指导和临床研究硕士学位（MCR），以及MDACC的活跃NCRR K30奖。申请中还提出了一个新颖的T32申请，主要面向博士预科学生，提供社区卫生科学、生物医学科学和/或生物医学信息学的硕士和博士学位组合，以及一个K12申请，面向博士后实习生和初级教员。CCTS还将包括核心转化实验室，包括一个分型/测序中心，一个提供DNA微阵列、RT-PCR和蛋白质组学服务的生物标志物中心，一个免疫监测中心，一个核磁共振成像中心和一个生物银行中心。一个由成就卓著的转化和临床研究人员、基础科学家和教育工作者以及社区代表组成的CCTS“智库”将作为“创新引擎”聚集在一起，提出并建议将新颖和新兴的科学信息、方法和技术应用于跨专业、学科和社区的人类健康和疾病研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The University of Texas Health Science Center at Houston (UTHSC-H) proposes to establish a Center for Clinical and Translational Sciences (CCTS) in the Texas Medical Center (TMC), Houston, Texas. Participating faculty and trainees in the CCTS will include those from the UTHSC-H component degree granting schools, including its School of Medicine, School of Public Health, Graduate School of Biomedical Sciences, School of Health Information Sciences, School of Nursing, Dental School and Institute of Molecular Medicine (IMM), as well as collaborating faculty/facilities from the UT M.D. Anderson Cancer Center (MDACC) and which also is located in the TMC. The academic "home" for the CCTS will be located in 11,422 sq ft of newly renovated and CCTS-designated space at the UTH Medical School which is physically joined to the Memorial Hermann Hospital (MHH) and serves as its partner and major teaching hospital. The CCTS "home" will administer all aspects of the CCTS and provide space and resources for faculty and trainees, along with expertise in study design, biostatistics, regulatory issues, ethics, and bioinformatics, and funding of Pilot and Feasibility Studies, provision of resources and protected time for clinical and translational faculty and trainees and interactions/collaborations with the various communites and industry. For Participant and Clinical Interactions Resources (PCIR), the CCTS will subsume the UTHSC-H General Clinical Research Center (GCRC) at MHH, the satellite UTHSC-H GCRC at Brownsville, Texas, and, in part, the MDACC Clinical and Translational Research Center to enhance research productivity and efficiency. In its Educational Component, the CCTS will subsume, in part, the current Center for Clinical Research and Evidence-Based Medicine, which has developed and currently provides formal classes, mentoring, and a Masters Degree in Clinical Research (MCR) at UTHSC-H, and an active NCRR K30 award at MDACC. Also proposed in the application is a novel T32 application offering combinations of Masters and PhD degrees in Community Health Sciences,'Biomedical Sciences and/or Biomedical Informatics, primarily for pre-doctoral students, and a K12 application for post-doctoral trainees and junior faculty. The CCTS also will subsume Core Translational Laboratories, including a enotyping/Sequencing Corel a Biomarkers Core offering DNA Microarray, RT-PCR and Proteomics services , an Immune Monitoring Core, an MRI Imaging Core, and a Biobanking Core. A CCTS "Think Tank" comprised of highly accomplished translational and clinical Investigators, basic scientists and educators, and community representatives, will come together as an "engine for innovation" to bring forward and recommend the application of novel and emerging scientific information, methods and technologies to research into human health and diseases across specialties, disciplines and communities.