AGE CHANGES IN PULMONARY FUNCTION

BLSA肺老化计划的重点是： a.健康非吸烟男性和女性FEV 1的纵向变化 对91名男性进行了FEV 1变化的纵向分析 和82名没有呼吸系统疾病史， 抽烟 FEV 1数据采用混合效应模型进行建模， FEV_1水平的回归模型和纵向百分位数分布 构建成 结果表明：（1）平均纵向率 男性FEV 1下降约为240-340 ml/10年， 2）没有一个参与者表现出持续的改善， FEV 1，3）男性受试者间变异性大于女性 在男性中随着年龄的增长而增加，但在女性中随着年龄的增长而减少。 的 按年龄和性别划分的百分位数分布是第一列线图 这反映了肺功能变异性的年龄差异。 B. 外周血白细胞计数与慢性粒细胞白血病纵向变化的关系 健康BLSA受试者的FEV 1。 白细胞计数对 正在使用纵向变化研究呼吸功能， 健康非吸烟BLSA受试者的FEV 1作为结局。 C. 年龄相关的最大吸气压（MIP）变化。 横 对400名男性和295名女性的数据进行了分段分析， 年龄在20到90岁之间。 女性的平均MIP 在不同年龄组中，妇女的性别比例约为男子的三分之二。 正在构建健康亚组MIP的参考方程。

The BLSA Program in Pulmonary Aging has focused on: a. Longitudinal changes in FEV1 in healthy, non-smoking men and women. Longitudinal analyses of changes in FEV1 were conducted among 91 men and 82 women who had no history of respiratory problems and had never smoked cigarettes. The FEV1 data were modeled using a mixed-effects regression model and longitudinal percentile distributions of FEV1 level were constructed. The findings showed 1) the average longitudinal rate of decline in FEV1 was approximately 240-340 ml/decade in men and women, 2) none of the participants exhibited a sustained improvement in FEV1, and 3) between-subjects variability is greater in men than women and increases with age in men, but decreases with age in women. The age- and gender-specific percentile distributions are the first nomograms which reflect age differences in the variability in pulmonary function. b. Relationship of peripheral leukocyte count to longitudinal changes in FEV1 in healthy BLSA subjects. The effect of leukocyte count on ventilatory lung function is being studied using longitudinal changes in FEV1 of healthy nonsmoking BLSA subjects as outcome. c. Age associated changes in Maximal Inspiratory Pressure (MIP). Cross sectional analyses of data consisting of 400 men and 295 women ranging in age between 20 and 90 years were done. The average MIP of females across the different age groups was about two thirds that of men. Reference equations for MIP in a healthy subset are being constructed.