Pittsburgh Resuscitation Network

描述（由申请人提供）： 本申请描述了匹兹堡作为临床研究联盟中的区域临床中心（RCC）可以提供的独特资源，以改善复苏结果。匹兹堡已经组建了一个多学科团队，致力于改善心血管稳定性的恢复和最大限度地减少脑损伤。独特的资源包括与区域紧急医疗服务，该地区最繁忙的创伤中心之一，综合医疗保健系统，以及专注于复苏的核心研究人员的强有力的工作关系。我们已经纳入了标准化护理计划，确保方案依从性，并进行详细的功能结局评估。我们有机制来控制在现场、急诊室、重症监护室、康复中心和功能评估时对受试者的干预。心肺骤停和创伤患者的基线特征适合于临床研究。目前，我们每年为超过500人监测心肺骤停后的复苏和结果。目前，我们每年治疗3600多名创伤患者。每年有超过500名创伤患者的损伤严重度评分为15或更高，并且每年约有150名创伤患者使用当前疗法具有致命的创伤性损伤。两个概念试验是为财团。第一项研究将研究（1）每单位时间内胸部按压次数的增加和（2）诱导低温的不同持续时间对心肺骤停后生存和恢复的影响。第二部分将研究创伤失血性休克后有意诱导轻度低温的效果。一个临床研究培训核心也描述了在财团内培训一名年轻的调查员的目的。

DESCRIPTION (provided by applicant): This application describes the unique resources Pittsburgh can provide as a Regional Clinical Center (RCC) in a Clinical Research Consortium to Improve Resuscitation Outcomes. Pittsburgh has assembled a multidisciplinary team dedicated to improving restoration of cardiovascular stability and minimizing brain injury. Unique resources include a strong working relationship with regional emergency medical services, one of the busiest trauma centers in the region, an integrated health care system, and a core of researchers focused on resuscitation. We have included plans to standardize care, assure protocol compliance, and perform detailed functional outcome assessment. We have mechanisms to control interventions for subjects in the field, in the emergency department, in the intensive care unit, in rehabiliation and at the time of functional evaluation. The baseline characteristics of cardiopulmonary arrest and traumatized patients are suitable for clinical research. We currently monitor the resuscitation and outcomes after cardiopulmonary arrest for over 500 individuals each year. We currently treat over 3600 trauma patients per year. Over 500 trauma patients per year have injury severity scores of 15 or greater, and about 150 trauma patients per year have fatal traumatic injuries using current therapy. Two concept trials are presented for the Consortium. The first will study (1) an increase in the number of chest compressions delivered per unit time and (2) different durations of induced hypothermia on survival and recovery after cardiopulmonary arrest. The second will examine the effect of intentional induction of mild hypothermia after trauma with hemorrhagic shock. A clinical research training core is also described for purposes of training a young investigator within the Consortium.