MBRS SCORE Program at Texas A&M University-Kingsville

描述（由申请人提供）：MBRS SCORE计划在得克萨斯A&M大学金斯维尔包括以下主要目标：（1）建立和提供支持，为适当的生物医学研究环境在TAMUK;（2）提供一个合适的基础设施，允许参与研究人员检查生物医学研究的关键方面;以及（3）提供关于生物医学相关性和重要性问题的大量和重要的数据和信息。 五个提案是以前资助的项目，包括细胞凋亡，母体压力对免疫系统的影响，神经遗传学，毒液去整合素作用和视神经再生。十项提案是新提交的，包括细菌基因簇的功能分析，禽流感病毒亚型的监测，蚊子中基于转座子的转基因，卵巢基因表达的转录调节，黄体组织发育和不育，维生素B6衍生物介导的缺血性心脏病的衰减，蛋白质组学和质谱法，生殖内分泌学，骨质疏松症中的柑橘衍生化合物，以及药物滥用对健康的影响。 这十个新项目，加上五个以前资助的项目，将支持七个不同部门的研究，并为参与教师提供理想的机会，以扩大和加强他们的个人研究计划。个人研究者的研究目标也将为本科生和研究生在生物医学研究的关键方面的培训提供极好的机会，并为生物医学研究的未来职业生涯做好适当的准备。

DESCRIPTION (provided by applicant): The MBRS SCORE program at Texas A&M University-Kingsville consists of the following primary objectives: (1) establish and provide support for an appropriate biomedical research environment at TAMUK; (2) provide a suitable infrastructure that permits participant investigators to examine key aspects of biomedical research; and (3) provide substantial and significant data and information regarding questions of biomedical relevance and importance. Five proposals are previously funded projects encompassing apoptosis, maternal stress effects on the immune system, neurogenetics, venom disintegrin action, and optic nerve regeneration. Ten proposals are new submissions and encompass functional analysis of a bacterial gene cluster, surveillance of avian influenza virus subtypes, transposon-based transgenesis in mosquitoes, transcriptional regulation of ovarian gene expression, luteal tissue development and infertility, vitamin B6 derivative-mediated attenuation of ischemic heart disease, methodologies in proteomics and mass spectrometry, reproductive endocrinology, citrus-derived compounds in osteoporosis, and health consequences of substance abuse among high school students. Together these ten new projects, in addition to the five previously funded projects, will support research in seven different departments and provide ideal opportunities for the participant faculty to expand and enhance their individual research programs. The research goals of the individual investigators will also provide excellent opportunities for the training of undergraduate and graduate students in key aspects of biomedical research as well as suitable preparation for future careers in biomedical research.