EMERGENCE OF COMPLEX DYNAMICS IN SIMPLE SIGNALING NETWORKS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。生理学中一个具有挑战性的问题是控制系统输出1/f波动的起源及其随疾病和衰老的变化。有人提出，1/f波动是由于多个底层控制系统的相互作用。我们正在研究小世界布尔网络——一个简单的信号网络模型，它可以在一定条件下产生1/f波动。该模型还可用于模拟病理条件下神经网络的退化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A challenging problem in physiology is the origin of 1/f fluctuations in the output of control systems and their alteration with disease and aging. It has been proposed that 1/f fluctuations are due to the interactions of multiple underlying control systems. We are studying small-world Boolean networks - a simple model for signaling networks that can generate 1/f fluctuations under certain conditions. The model can also be used to simulate the degradation of the networks under pathologic conditions.