Training in Vascular Biology and Medicine

描述(由申请者提供)：这笔培训基金的主要重点是从跨学科的角度为来自多个参与部门的研究员提供血管生物学培训，特别强调将基本发现转化为临床研究和实践。科学界和临床界以及美国心脏协会和美国国立卫生研究院等国家组织都认识到血管生物学和医学综合项目的重要性和稀缺性。在印第安纳大学，在过去的4年里，我们开发了一个多学科的血管生物学和医学项目，由来自基础和临床部门的32名研究人员组成。这些人包括来自10个临床分部和科室的研究人员，以及6个基础科学系或工程学(普渡)。该中心为这些研究人员之间的合作提供了一个高度互动的环境，这反映在几个新的小组活动的出现和非常积极的参与上，这些活动有助于建立一个强大的培训环境：一个血管生物学研讨会系列，一个血管期刊俱乐部，两个血管研究讨论小组，每个小组的目标都是最终提交PPG或SCOR多名研究人员补助金。ICVBM内部发生的新合作也直接导致了大量新的联邦资金。在过去的两年里，该中心赞助了血管生物学和医学方面的内部赠款：在提交的20项建议中，有10项是基于其科学价值、部门间性质和未来资金扩展前景而获得的；这些直接导致了6项新的联邦或国家赠款--证实了这些互动的优点。这一对血管生物学和医学未来的互动愿景是由一项严格的研究培训计划推动的，该计划整合了血管生物学的所有方面，并鼓励将基本发现转化为临床实践，并培养年轻的研究人员成为该领域的未来领导者。这项T32计划旨在为来自临床和基础研究背景的博士后研究员提供一个机会，让他们沉浸在这个丰富和互动的环境中的选定实验室。

DESCRIPTION (provided by applicant): The primary focus of this training grant is to provide vascular biology training to fellows from multiple participating Divisions and Departments, from an interdisciplinary perspective with a particular emphasis on translation of basic findings into clinical research and practice. The importance, as well as rarity, of an integrated program in vascular biology and medicine is recognized by both scientific and clinical communities, and by national organizations such as the American Heart Association, and National Institutes of Health. At Indiana University, over the past 4 years, we have developed a multidisciplinary program in Vascular Biology and Medicine, comprised of 32 investigators from basic as well as clinical departments. These include investigators from 10 clinical divisions and departments, as well as 6 basic science departments or Engineering (Purdue). This center has made possible a highly interactive environment for collaboration among these investigators, which has been reflected in emergence of and very active participation in several new group activities which lend themselves to a robust training environment: a vascular biology seminar series, a vascular journal club, two vascular research discussion groups, each targeted toward the eventual submission of a PPG or SCOR multi-investigator grant. The new collaborations that have occurred within the ICVBM have also led directly to substantial new federal funding. Over the past 2 years, the Center sponsored intramural grants in vascular biology and medicine: of 20 submitted proposals, 10 were awarded based on their scientific merit, interdepartmental nature, and prospects for extension to future funding; and these have led directly to 6 new federal or national grants - a corroboration of the merit of these interactions. This interactive vision for the future of vascular biology and medicine is being advanced by a rigorous research training program integrates all aspects of vascular biology and encourages the transfer of basic discoveries to clinical practice, and which nurtures young investigators to become the future leaders of this field. This T32 proposal is designed to provide an opportunity for selected post-doctoral fellows from both clinical and basic research backgrounds to be immersed in selected laboratories within this rich and interactive environment.