EXPERIMENTAL THERAPEUTICS IN CRITICAL ILLNESS

描述（由申请人提供）： 超出所提供的空间。 这个博士后培训计划的建议是为了培养研究员，为期2或3年，在基础科学研究有关心肺和肾脏对压力的反应。学员的总体研究重点是基础科学调查的四个相互关联的层次：1）细胞和分子免疫生物学; 2）器官损伤的细胞基础; 3）器官系统相互作用;和4）基于结果的研究。这种方法强调了重症监护医学的重要基础，需要将细胞和分子生物学整合到器官系统监测中，并遵循治疗方法以确定其对社会相关结果的影响。这些研究领域与教师合作的校外研究赠款相吻合。研究计划是培训的极好工具，因为它们提出了广泛的问题，可以在这些问题上进行精确的、目标明确的个人研究培训工作。教师反映了一个经验丰富和专门的资深院士群体，都有校外研究培训支持和培训经验。在完成培训计划后，研究员将了解如何设计，执行和完成实验，以回答来自重症患者的特定问题。因此，研究员不仅要接受先进的实验室方法学的培训，还要接受将未来的实验问题应用于危重患者真实的生活问题所需的思维过程的培训。所有受训人员将参加匹兹堡大学基础科学系提供的正式研究生课程。有些人可能会完成必要的课程，以获得高级学位。大多数培训将在主要培训员的实验室进行，采用经过仔细考虑的师徒制。这种培训技术结合了学员和培训师之间的每周会议以及一个小时的研究培训研讨会。此外，受训人员将每两年向当地研究界作一次正式的研究报告。

DESCRIPTION (provided by applicant): EXCEED THE SPACE PROVIDED. This postdoctoral training program proposal is designed to train fellows, for a period of 2 or 3 years each, in basic science research relevant to cardiopulmonary and renal responses to stress. The overall research focus of the trainees is on four inter-related levels of basic science investigation: 1) cell and molecular immunobiology; 2) cellular basis of organ injury; 3) organ-system interaction; and 4) outcomes-based research. This approach underscores the essential basis of critical care medicine, requiring an integration of cell and molecular biology to organ-system monitoring, and following therapies to define their effects on socially relevant outcomes. These areas of research coincide with extramural research grants on which the faculty collaborate. The research plans are excellent vehicles for training because they ask broad questions on which precise, well-targeted individual research training efforts can be staged. The faculty reflect an experienced and dedicated group of senior academicians, and all have extramural research training support and training experience. Upon completion of the training program, the fellow will understand how to design, execute, and complete experiments to answer specific questions derived from critically ill patients. Thus, the fellow will be trained not only in advanced laboratory methodology, but also in the thought processes needed to apply future experimental problems as they relate to real life problems in critically ill patients. All trainees will take formal postgraduate courses offered by the basic science departments of the University of Pittsburgh. Some may complete coursework necessary to receive advanced degrees. Most training will take place in the laboratories of the principal trainers using a carefully thought-out version of the master-apprentice system. This training technique combines weekly meetings between the trainee and trainer as well as a one hour research training seminar. Furthermore, formal research presentations by the trainees will be given biannually to the local research community.