Heart-Lung Interactions & Cardiovascular Insufficiency

心肺相互作用

• 批准号: 6741841
• 负责人: MICHAEL R PINSKY
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741841
• 关键词: bioimaging /biomedical imaging; cardiopulmonary disease; cardiovascular imaging /visualization; echocardiography; heart contraction; heart function; hemodynamics; human subject; patient oriented research; positive pressure breathing; pulmonary respiration; pulse pressure wave; respiratory imaging /visualization; vasomotion

We shall use the clinical analysis of heart-lung interactions as the vehicle for training post-doctoral candidates. This is an excellent and proven productive pathway for mentoring because it is based in clinically relevant cardiopulmonary physiology and requires the trainee to learn to use state-of-the-art imaging techniques with broad applications to the operating room, ICU, general hospital ward and out- patient clinic. Ventilation and ventilatory maneuvers have profound and often poorly understood hemodynamic effects especially in the setting of cardio-respiratory failure. Although numerous investigators have studied heart-lung interactions, an accurate clinical application has been lacking. Our goal is to develop and validate clinically relevant and easily applicable bedside tools for the rapid and unambiguous diagnosis of the etiology of hemodynamic insufficiency and the impact of ventilatory and adjunct cardiovascular therapies upon it. We use as our research environment, the echocardiographic clinic and the cardiac surgery suite. To accomplish these goals we are testing three hypothesis: 1) Ventilation-induced changes in LV preload and afterload are non-linear between forceful and relaxed spontaneous and positive- pressure inspiration. 2) Low levels of positive end-expiratory pressure improve LV performance by minimizing ventricular interdependence and LV ejection asynchrony by increasing ITP. 3) LV contractile reserve and preload responsiveness (often opposite ends of the cardiac function spectrum) and arterial tone can be readily identified by analysis of the arterial pulse pressure responses to spontaneous and positive-pressure ventilation. We shall use state-of-the-art echocardiographic imaging techniques (acoustic quantification and tissue Doppler imaging) for complex analysis of LV performance and simple aortic-pulsed Doppler and arterial pressure waveform analysis to assess preload-responsiveness, contractile reserve and arterial tone to derive clinically useful information.

我们将使用心肺相互作用的临床分析作为培养博士后候选人的工具。这是一种优秀且经过验证的有效指导途径，因为它基于临床相关的心肺生理学，要求受训者学习使用最先进的成像技术，广泛应用于手术室、ICU、综合医院病房和门诊。通气和辅助操作对血流动力学的影响很大，但人们对这种影响了解甚少，特别是在心肺衰竭的情况下。虽然许多研究人员已经研究了心肺相互作用，但缺乏准确的临床应用。我们的目标是开发和验证临床相关的和易于应用的床边工具，用于快速和明确的诊断血流动力学功能不全的病因，以及辅助和辅助心血管治疗对其的影响。为了实现这些目标，我们测试了三个假设：1）在强有力和放松的自发和正压吸气之间，LV前负荷和后负荷的通气诱导变化是非线性的。2)低水平的呼气末正压通过减少心室相互依赖性改善LV性能，通过增加ITP改善LV射血功能。3)LV收缩储备和前负荷反应性（通常是心脏功能谱的两端）和动脉张力可以通过分析对自发和正压通气的动脉脉压反应来容易地识别。我们将使用最先进的超声心动图成像技术（声学定量和组织多普勒成像）对LV性能进行复杂分析，并使用简单的多普勒脉冲和动脉压波形分析来评估前负荷反应性、收缩储备和动脉张力，以获得临床有用的信息。