Training in Developmental Cardiovascular Biology

描述（由申请人提供）： 这项更新提案旨在继续21年前启动的心血管发育生物学计划培训。在过去10年中，该计划支持的11名研究员中，有5名在优秀机构担任学术职务，10名积极参与联邦或私人资助的研究计划。该计划将继续利用心血管研究所和几个UCSF部门的优秀生理学和分子及细胞生物学实验室来培训基础，临床和转化科学家，他们将在未来几十年内处于心血管发育研究的最前沿。现代生理学和分子生物学方法在我们对心血管生物学和疾病的认识方面取得了显着进展，人类遗传学和干细胞生物学领域提供了更多的机会。这些发展预示着科学的快速进步，并强调了对训练有素的研究人员的持续需求，以继续这项工作，并在基本发现和人类健康进步之间建立桥梁。为此，我们将：1.利用CVRI，儿科系和UCSF在基础生物学，临床流行病学和转化研究领域的独特培训机会。2.招聘顶尖博士毕业生还有医学博士博士心血管研究的职业计划。3.将联合收割机临床儿科心脏病学培训与基础或临床/转化研究的严格基础相结合，以促进医生-科学家的培训。该补助金将支持6名博士后研究员，每人为期2年，并设有三个轨道。轨道I学员将是寻求临床儿科心脏病学和基础科学研究培训的医学博士。此方向的学员将仅在其培训的研究部分获得此培训补助金的支持。第二轨道学员将是博士或医学博士-博士们将公开竞争基础心血管生物学的博士后职位。Track III学员将是寻求与心血管健康和疾病相关的临床或转化研究高级培训的医学博士。将在丰富的科学环境中提供强有力的教学课程，包括严格的研究生课程和定期的学员会议。每位学员将与25位杰出的项目教师导师之一执行一个研究项目。

DESCRIPTION (provided by applicant): This renewal proposal seeks continuation of the Training in Developmental Cardiovascular Biology Program, initiated 21 years ago. Of the 11 fellows supported by this Program over the previous 10 years, and who have completed the program, 5 have academic appointments at outstanding institutions and 10 are actively engaged in federally- or privately-funded research programs. This Program will continue to utilize the outstanding physiology and molecular and cellular biology laboratories at the Cardiovascular Research Institute and several UCSF departments to train basic, clinical, and translational scientists who will be at the forefront of developmental cardiovascular research in the coming decades. Modern physiologic and molecular approaches have produced remarkable advances in our knowledge of cardiovascular biology and disease, and the fields of human genetics and stem cell biology are providing still more opportunities. These developments promise rapid scientific progress and underscore the ongoing need for well-trained investigators to both continue this work and build bridges between basic discovery and the advancement of human health. To this end we will: 1. Exploit the unique training opportunities in the CVRI, the Department of Pediatrics, and UCSF in general, in areas of basic biology, clinical epidemiology, and translational research. 2. Recruit graduates of top Ph.D. and M.D.-Ph.D. programs to careers in cardiovascular research. 3. Combine clinical pediatric cardiology training with a rigorous grounding in basic or clinical/translational research to facilitate the training of physician-scientists. This grant will support 6 postdoctoral fellows, each for 2 years, and features three Tracks. Track I trainees will be M.D.s seeking both clinical pediatric cardiology and basic science research training. Trainees in this Track will receive support from this training grant only for the research component of their training. Track II trainees will be Ph.D.s or M.D.-Ph.D.s who will compete openly for postdoctoral positions in basic cardiovascular biology. Track III trainees will be M.D.s seeking advanced training in clinical or translational research relevant to cardiovascular health and disease. A strong didactic curriculum will be provided in a rich scientific environment with rigorous graduate courses and regular trainee meetings. Each trainee will execute a research project with one of the 25 outstanding program faculty preceptors.