CSHL Course on Yeast Genetics and Genomics

描述（由申请人提供）：冷泉港实验室酵母遗传学和基因组学课程建议继续在培训新使用酿酒酵母进行生物学研究的研究人员方面发挥关键作用的悠久传统。最近的头衔变更反映了更强调让参与者熟悉基因组学和蛋白质组学中最新技术的使用。这三周的高度密集课程的目的是使每个学生精通酵母遗传学的基础知识，然后建立概念骨干为更复杂的方法，涵盖为课程进展。实验室实验分为十二个多部分的部分，涵盖各种主题，包括：1。使用酵母的基本原理；2. 酵母分子生物学概论；3. 遗传和物理相互作用分析；和4。基因组学。课程的实验部分由每天的理论讲座进行补充，这些讲座是由在系统中经过验证的专业知识和由知名研究人员利用酵母系统的世界级系列研讨会选择的讲师进行的。因此，每个学生都能接触到他们所教授的方法的基本原理，以及该领域专家最先进的应用。该课程已经建立了良好的声誉，并寻求继续为不同的生物学家社区服务，包括来自不同背景的科学家，如进化生物学，定量生物学，以及在其他系统中工作的生物学家，这些系统可以证明利用酵母的明显好处，因为有大量资源可用于这种模式生物的功能基因组研究。此外，寻求将酵母方法纳入本科课程的教育工作者偶尔也是课程中的学生。虽然课程的总体组织每年都保持不变，但随着酵母生物学和基因组学的广泛领域的变化，内容也会自然演变；随着教师的更替（每年约1人），新的专业知识被添加到课程中，新教师将最新的技术和方法纳入课程。由于每年至少有两名教官留下来，这种演变并不是以牺牲连续性为代价的。

DESCRIPTION (provided by applicant): The Cold Spring Harbor Laboratory Yeast Genetics and Genomics Course proposes to continue with a long tradition of serving a critical role in the training of investigators new to the use of S. cerevisiae for biological research. The recent title change reflects a greater emphasis on familiarizing participants with the use of the latest techniques in genomics and proteomics. This three-week highly intensive course is designed to make each student proficient in the fundamentals of yeast genetics which then establishes the conceptual backbone for the more sophisticated methods that are covered as the course progresses. The laboratory experiments are broken into twelve multi-part sections that cover a variety of topics including: 1. Fundamentals of working with yeast; 2. Introduction to yeast molecular biology; 3. Genetic and physical interaction analysis; and 4. Genomics. The experimental portion of the course is complemented by daily theoretical lectures by the instructors chosen for their proven expertise in the system and a world-class seminar series from renowned investigators that utilize the yeast system. As a result every student is exposed to the underlying principles of the methods they are being taught and their state-of-the-art application by the experts in the field. The course has a well-established reputation for, and seeks to continue, serving a diverse community of biologists that include scientists from disparate backgrounds such as evolutionary biology, quantitative biology, as well as biologists working in other systems that can prove a clear benefit from the utilization of yeast, given the large number of resources available for functional genomic studies in this model organism. In addition, educators that seek to incorporate yeast approaches in undergraduate courses are occasional students in the course. Although the general organization of the course is intended to remain the same from year to year, there is a natural evolution in content as the broad field of yeast biology and genomics changes; as instructors are replaced (~1 per year) new expertise is added to the course and the latest technologies and approaches are incorporated into the curriculum by the new instructors. Since at least two instructors remain from year to year, this evolution does not come at the sacrifice of continuity.