Enzyme Responsive Materials for Biology and Medicine

本研究的目的是开发新的途径，以合理设计的酶响应材料（ERMs）的生物医学应用。这些材料可以改变性质，例如它们可以响应于生化反应而膨胀/塌陷或从溶液变为凝胶。这些材料可应用于响应疾病特异性酶的药物的控制释放。它们也可以用于触发组装用于细胞生长的基质，并应用于组织工程。该项目的成果将是（i）新的交互式生物材料的开发和全面表征，（ii）增加对分子水凝胶中结构/功能关系的基本理解，（iii）3D细胞培养支架的酶触发组装中的概念验证应用，以及（iv）酶触发药物递送。

This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.