Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC)

描述（由申请人提供）：五年的核心支持是要求堪萨斯精神发育迟滞和发育障碍研究中心（MRDDRC）的竞争性更新。堪萨斯MRDDRC，现在在其第39个年头，已经发挥了重要的国际作用，在产生高效的行为干预措施，目的是在原因，预防和治疗精神发育迟滞和相关的继发性疾病，并在划定典型和非典型发展的基础生物学的基本知识。自成立以来，该中心一直支持行为和生物学研究的平衡组合。基于这一丰富的历史，该中心在未来的独特贡献将是生物信息行为和药理学干预和治疗方法的发展。该使命的堪萨斯MRDDRC是支持高质量的基础和应用研究有关的原因和预防精神发育迟滞和预防和补救相关的继发性条件和相关的发展障碍。为了实现这一使命，堪萨斯MRDDRC旨在实现三个目标。首先，开发和支持新的跨学科的基础和应用研究的举措直接相关的中心的使命，汇集整个堪萨斯中心的科学家，以及促进与其他机构的研究人员的合作企业。第二，提供具有成本效益的、科学生成的、最先进的核心服务、资源和设施，直接提高中心研究者及其合作者产生的科学的质量和影响。第三，提供高效率、高成本效益的系统，以规划、开发、管理、协调和传播与中心相关的研究活动。堪萨斯MRDRC的研究计划围绕四个综合主题领域组织，每个领域都反映了MRDD的一般主题以及我们目前努力的科学方向和优势。这些主题是：1）智力低下的语言、交流和认知; 2）智力低下的风险、预防和干预; 3）智力低下的神经生物学; 4）早期发育的细胞和分子生物学。为了协调和支持与这些主题相关的76名研究人员和75个研究项目的研究活动，提出了四个核心单元：a）沟通和管理; B）生物行为测量; c）研究设计和分析; d）综合成像。

DESCRIPTION (provided by applicant): Core Support for five years is requested for the competitive renewal of the Kansas Mental Retardation and Developmental Disabilities Research Center (MRDDRC). The Kansas MRDDRC, now in its 39th year, has played a major international role in generating highly effective behavioral interventions aimed at the causes, prevention, and treatment of mental retardation and related secondary conditions, and in delineating basic knowledge of the underlying biology of typical and atypical development. Since its inception, the center has supported a balanced portfolio of behavioral and biological research. Building on this rich history, a unique contribution of the center in the future will be the development of biologically informed behavioral and pharmacological intervention and treatment approaches. The mission of the Kansas MRDDRC is to support high quality basic and applied research relevant to the causes and prevention of mental retardation and the prevention and remediation of associated secondary conditions and related developmental disabilities. To achieve this mission, the Kansas MRDDRC is designed to accomplish three objectives. First, to develop and support new interdisciplinary basic and applied research initiatives directly relevant to the center's mission, bringing together scientists across the Kansas Center as well as promoting collaborative ventures with researchers at other institutions. Second, to provide cost-effective, scientifically generative, state of the art core services, resources, and facilities that directly enhance the quality and impact of science produced by center investigators and their collaborators. Third, to provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and disseminating research activities associated with the center. The Kansas MRDDRC's research program is organized around four integrated thematic areas that each reflects a general topic central to MRDD as well as the scientific directions and strengths of our current efforts. These themes are: 1) language, communication, and cognition of mental retardation; 2) risk, prevention, and intervention in mental retardation; 3) neurobiology of mental retardation; 4) cellular and molecular biology of early development. To coordinate and support the research activities of the 76 investigators and 75 research projects associated with these themes, four core units are proposed: a) Communication and Administration; b) Biobehavioral Measurement; c) Research Design and Analysis; d) Integrative Imaging.