15th International RUNX Workshop

申请者描述(由申请者提供)：为2008年9月举行的第15届RUNX国际研讨会提供部分赞助。这次会议将由Lucio Castilla(马萨诸塞大学医学院)和J.Peter Gergen(石溪大学)共同组织。本次会议的目的是分享和讨论未发表的关于RUNX转录因子的调控和功能的研究，并促进对它们作为发育、分化和癌症多个过程的主要调节因子的理解的进展。由于RUNX功能的广泛性，该研讨会有着汇聚来自不同系统和多个领域的科学家的强大历史，包括发育生物学、病毒学、遗传学、结构生物学和癌症生物学。这一独特的群体包括那些最先确定RUNX因子、确定其功能和结构并表征所产生的白血病融合蛋白的人。研讨会将强调干细胞中指导RUNX功能的分子机制、细胞命运决定和癌症发展。之前的RUNX研讨会大大加快了发现的速度，并加深了我们对RUNX在发育和疾病中的功能的理解。第15届国际RUNX研讨会旨在保持这一传统，从而加强未来在癌症研究和治疗方面的努力。

DESCRIPTION (provided by applicant): Support is requested to provide partial sponsorship of the 15th International RUNX Workshop in September of 2008. This meeting will be co-organized by Lucio Castilla (University of Massachusetts Medical School) and J. Peter Gergen (Stony Brook University). The goals of this meeting are to share and discuss unpublished studies on the regulation and function of the RUNX transcription factors, and stimulate progress in the understanding of their role as master regulators of multiple processes in development, differentiation and cancer. Due to the wide spectrum of RUNX function, the Workshop has a strong history of bringing together scientists who work in diverse systems and from multiple fields, including developmental biology, virology, genetics, structural biology, and cancer biology. This unique group includes those who first identified the RUNX factors, defined their function and structure, and characterized the resulting leukemia fusion proteins. The Workshop will emphasize the molecular mechanisms directing RUNX function in stem cells, cell fate decisions, and cancer development. Previous RUNX Workshops have greatly accelerated the pace of discovery and enhanced our understanding of RUNX function in development and disease. The 15th International RUNX Workshop is intended to maintain this tradition, thereby serving to enhance future efforts in cancer research and treatment.